| IED ID | IndEnz0002013387 |
| Enzyme Type ID | protease013387 |
| Protein Name |
Mitochondrial respiratory chain complexes assembly protein rca1 EC 3.4.24.- |
| Gene Name | yta12 SPBC543.09 |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Enzyme Sequence | MRNPFLTFRAPTRKTGDYLVSKFVKKDNFSSLRLARAYTFSTRSTAVSQFSLLSLSQRSFQSLKINKGIPEKHKIPLISSKQFSVTSKRSQNGSSGSNSDANGRKNGQKNDDSKKKGLNGNDPKKVFEIALNGNTILGGILVAYILYNVLSPNANMQEITWQDFRQQFLDKGLVERLVVVNRNMVRVILRGGVASGSGQYYFSIGSIDSFDRKLEDAQRQLGIPPSEFVPVAYHDEVSVLATLLSFAPTLLIIGSVIYLSRRASGAAGGGQGGIFGIGKSRAKMFNHETDIKIKFADVAGVDEAKEEIMEFVKFLKNPKFYERLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFLEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGKARGRGGQFGSNDERESTLNQLLVEMDGFTSSEHIVVFAGTNRPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKVHLKHIKAADNIDLIAKRLAVLTSGFTGADIMNVCNEGALIAARSNSNEVQMVHFEQAIERVTAGLEKKSRVLSPEEKNTVAHHEAGHAVAGWFMEYVDPLLKVSIIPRAQALGYASYLPKDQYLMSRGQILDQMGMALAGRVSEEIFFGPEKITSGASDDFQKVTRMAQAYVTQYGMSPTVGTIAYPIDTRETVQKPFSEATAQMIDEEIRKLVKHAYERTKKLLLEHKQGLENIAQRLLQKEVITYNEVETILGPRPYAYKHLNISELMRQSEYKNDHDPRNPPIPPSPQQPSA |
| Enzyme Length | 773 |
| Uniprot Accession Number | Q9HGM3 |
| Absorption | |
| Active Site | ACT_SITE 562; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 336..343; /note=ATP; /evidence=ECO:0000255 |
| Features | Active site (1); Chain (1); Compositional bias (2); Metal binding (3); Nucleotide binding (1); Region (2); Transmembrane (2) |
| Keywords | ATP-binding;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Nucleotide-binding;Protease;Reference proteome;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20473289; 20621843; 21340088; 21354177; 23697806; 27918601; 34250083; |
| Motif | |
| Gene Encoded By | |
| Mass | 85,369 |
| Kinetics | |
| Metal Binding | METAL 561; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 565; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 638; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |