| IED ID | IndEnz0002013391 |
| Enzyme Type ID | protease013391 |
| Protein Name |
Tissue factor pathway inhibitor TFPI Extrinsic pathway inhibitor EPI Lipoprotein-associated coagulation inhibitor LACI |
| Gene Name | TFPI LACI TFPI1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM |
| Enzyme Length | 304 |
| Uniprot Accession Number | P10646 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Beta strand (16); Chain (1); Disulfide bond (9); Domain (3); Glycosylation (5); Helix (5); Mutagenesis (3); Natural variant (1); Signal peptide (1); Site (4); Turn (3) |
| Keywords | 3D-structure;Alternative splicing;Blood coagulation;Direct protein sequencing;Disulfide bond;Endoplasmic reticulum;GPI-anchor;Glycoprotein;Hemostasis;Lipoprotein;Membrane;Microsome;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform Alpha]: Secreted.; SUBCELLULAR LOCATION: [Isoform Beta]: Microsome membrane {ECO:0000269|PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:22144186}. |
| Modified Residue | |
| Post Translational Modification | PTM: O-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19017259, ECO:0000269|PubMed:8639592}. |
| Signal Peptide | SIGNAL 1..28; /evidence="ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:19017259, ECO:0000269|PubMed:2553722" |
| Structure 3D | NMR spectroscopy (2); X-ray crystallography (5) |
| Cross Reference PDB | 1ADZ; 1IRH; 1TFX; 4BQD; 4DTG; 5NMV; 6BX8; |
| Mapped Pubmed ID | 11057878; 11380428; 11460016; 11686353; 11693665; 11697721; 11776326; 11776329; 11816723; 11848461; 11864704; 12028585; 12038800; 12117418; 12193974; 12195688; 12270558; 12408975; 12428111; 12482841; 12540955; 12818258; 12871406; 14610342; 14656922; 15299926; 15307537; 15339683; 15351861; 15467908; 15572765; 15604416; 15817451; 15845911; 15886798; 15892865; 16113753; 16246254; 16247609; 16270631; 16380494; 16431924; 16488980; 16516912; 16765424; 16879232; 17003923; 17082321; 17180732; 17196206; 17469034; 17704111; 17762532; 17890962; 17931693; 17951326; 18045239; 18067603; 18094465; 18180609; 18217145; 18310227; 18327407; 18419747; 18600090; 18677291; 18690350; 18695356; 18977990; 19007969; 19012190; 19016004; 19065458; 19132232; 19169266; 19238444; 19244162; 19277407; 19350127; 19401682; 19411818; 19467658; 19630792; 19631649; 19689998; 19859836; 19913121; 20002538; 20034913; 20057044; 20062932; 20088940; 20124702; 20128871; 20140262; 20431849; 20442653; 20444258; 20453636; 20492471; 20519147; 20523161; 20978710; 21029363; 21132373; 2122883; 21293010; 21344386; 21474669; 21555871; 21664032; 21849050; 21868574; 21895962; 21979881; 22178066; 22363056; 22449009; 22461171; 22563084; 22627666; 22632032; 22658294; 22749962; 22836130; 22900482; 22918506; 22985614; 23038262; 23071754; 23074276; 23327927; 23348798; 23374966; 23407778; 23524311; 23530052; 23841464; 23979162; 24094893; 24127605; 24226152; 24233486; 24233490; 24275667; 24448154; 24461489; 24620349; 24716194; 24740810; 24966616; 25163770; 25303460; 25348176; 25617766; 25712553; 25864889; 25879386; 25882602; 26163243; 26233570; 26377606; 26496276; 26598923; 26681757; 26765308; 26826018; 26945263; 26968713; 26999003; 26999742; 27207418; 27801970; 28211163; 28246607; 28393401; 28421636; 28482260; 28521572; 28569919; 28712870; 28716011; 28749986; 28894953; 28983056; 29452445; 29532595; 29864781; 30366247; 30439766; 30695687; 30700553; 30861202; 30896671; 30952698; 32445923; 32877953; 33465109; 33529886; 33827254; 34876522; |
| Motif | |
| Gene Encoded By | |
| Mass | 35,015 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |