| IED ID | IndEnz0002013446 |
| Enzyme Type ID | protease013446 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase 26 EC 3.4.19.12 Deubiquitinating enzyme 26 Ubiquitin thioesterase 26 Ubiquitin-specific-processing protease 26 |
| Gene Name | UBP26 Os03g0192800 LOC_Os03g09260 OsJ_009385 |
| Organism | Oryza sativa subsp. japonica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice) |
| Enzyme Sequence | MSRPNTRNKSKRPRADDCESPSAVFKKIHSTGAITKGDIKQLYMVWKPVCHGCHGNSKDSPNCFCGLIPAANGVRKSGLWQRTNEIIRALGPNPSTDLRDSTETPAGLTNLGATCYANSILQCLYMNTSFRLGIFSLEPDILKMHPVLDQLARLFAQLHSSKMAFIDSAPFIKTLELDNGVQQDSHEFLTLFLSLLEGSLSHSKVPGARTIVQHLFRGSVSHVTRCSSCGRDSEASSKMEDFYELELNIKGLNNLEQSLDDYLSTEALDGENQYFCESCQKRVDATRCIKLRSLPPVVNFQLKRYVFLPKTTTKKKISSAFSFPGQLDMGKRLSNPSSSYTYGLSAILIHKGSAANSGHYVAHVKDESNGQWWEFDDEHVSKLGLHPFGEKPGKSSDKTDQKPQGSSTADSVTNDDNNSCHEAAFTSTMEEMFSSTDAYMLMYKRIAKDENGIESNNISSNNSLPHHFVDEIDERNTSYVKECEEYESKKDVHLAYITERRQEVKSVLTEAPATPEEDSYFWISTDWLRQWADNVNPPSPIITGVRVHSSIDNSPIQCEHGKVPASKVTSMKRLSAGAWHKLFSKYGGGPTLSSDDFCMECLKDGAKNSVSADVYRDRKASLRSIAEAALAGNNPDGPLYFVSRPWLTQWLRRKNVDIPSDADSGPTIALTCTHGNLLPEHASGAKRVTVPEDLWLFLYETSGMKIDDIVTFPSDSQPCGICSQQLSVVASVEDNLRAVKLKQRQSHEKLTSGKSLALHPGQKYYLVPSSWLSEWRAYITATGKNISSLPEPQSLEVTINSLICEKHSRLLQRPLDLVCKRGTITQKASNTDGLTMISESDWILFSEEWNVAHGKGLCAEIVFSKSSQDNLQSSEAVPILVEDLDQSTNDLSNDLGGREPYVRTDPEVCEECIGEKESCALVEKLNYQNEDIQVYLVRGKEAPKSIREASAAVPVPDRRTSKRSRRTTSGNSISLKVSGSTTVYQLKLMIWESLGIVKENQELHKGSVEIEDDFATLADKCIFPGDVLWVKDSEIYENRDIADEISEQKVVVQTEEGFRGTLLTSSASAQLCQDISFSD |
| Enzyme Length | 1079 |
| Uniprot Accession Number | A3AF13 |
| Absorption | |
| Active Site | ACT_SITE 115; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 359; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (2); Domain (5); Erroneous gene model prediction (2); Region (3) |
| Keywords | Hydrolase;Nucleus;Protease;Reference proteome;Repeat;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 119,884 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |