IED ID | IndEnz0002013472 |
Enzyme Type ID | protease013472 |
Protein Name |
Kunitz-type serine protease inhibitor DrKIn-I Daboia russelii Kunitz Inhibitor-I |
Gene Name | |
Organism | Daboia russelii (Russel's viper) (Vipera russelii) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Viperinae (vipers) Daboia Daboia russelii (Russel's viper) (Vipera russelii) |
Enzyme Sequence | MSSGGLLLLLGLLTLWAELTPISGQDRPKFCNLAPESGRCRGHLRRIYYNPDSNKCEVFFYGGCGGNDNNFETRKKCRQTCGAPRKGRPT |
Enzyme Length | 90 |
Uniprot Accession Number | H6VC05 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Serine protease inhibitor. Inhibits activated protein C (APC) with an IC(50) of 3.5 nM in the presence of heparin (to which it strongly binds) and an IC(50) of 88.9 nM in its absence. Other targets are also significantly inhibited in presence of heparin: trypsin (PRSS1) (45%), coagulation FXIa (F11) (40%), and plasmin (PLG) (70%). In vivo, synergizes with RVV-X in promoting coagulation in mice and by extension in Russell's viper bite patients. {ECO:0000269|PubMed:22416129}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1); Disulfide bond (3); Domain (1); Modified residue (1); Region (2); Signal peptide (1); Site (1) |
Keywords | Blood coagulation cascade activating toxin;Disulfide bond;Hemostasis impairing toxin;Protease inhibitor;Pyrrolidone carboxylic acid;Secreted;Serine protease inhibitor;Signal;Toxin |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
Modified Residue | MOD_RES 25; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000250 |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..24 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 10,010 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |