| IED ID |
IndEnz0002013510 |
| Enzyme Type ID |
protease013510 |
| Protein Name |
Tissue factor
TF
Coagulation factor III
Thromboplastin
CD antigen CD142
|
| Gene Name |
F3 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS |
| Enzyme Length |
295 |
| Uniprot Accession Number |
P13726 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269|PubMed:12652293}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (2); Beta strand (21); Chain (1); Disulfide bond (2); Glycosylation (2); Helix (6); Lipidation (1); Motif (3); Natural variant (4); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (1) |
| Keywords |
3D-structure;Alternative splicing;Blood coagulation;Disulfide bond;Glycoprotein;Hemostasis;Lipoprotein;Membrane;Palmitate;Reference proteome;Secreted;Signal;Transmembrane;Transmembrane helix |
| Interact With |
P55085; P08709; Q9UM19 |
| Induction |
INDUCTION: TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. {ECO:0000269|PubMed:19168442}. |
| Subcellular Location |
SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000269|PubMed:12652293}; Single-pass type I membrane protein {ECO:0000269|PubMed:12652293}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:12652293}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..32 |
| Structure 3D |
NMR spectroscopy (4); X-ray crystallography (45) |
| Cross Reference PDB |
1AHW;
1BOY;
1DAN;
1FAK;
1J9C;
1JPS;
1O5D;
1TFH;
1UJ3;
1W0Y;
1W2K;
1WQV;
1WSS;
1WTG;
1WUN;
1WV7;
1Z6J;
2A2Q;
2AEI;
2AER;
2B7D;
2B8O;
2C4F;
2CEF;
2CEH;
2CEZ;
2CFJ;
2EC9;
2F9B;
2FIR;
2FLB;
2FLR;
2HFT;
2PUQ;
2ZP0;
2ZWL;
2ZZU;
3ELA;
3TH2;
3TH3;
3TH4;
4IBL;
4M7L;
4YLQ;
4Z6A;
4ZMA;
5W06;
6R2W;
6Z9W;
|
| Mapped Pubmed ID |
11583305;
11601848;
11744662;
11776298;
11816707;
11816709;
11858183;
11858185;
11858480;
11876644;
11882315;
11921018;
11929768;
11943929;
11973337;
11994566;
12008961;
12019261;
12028585;
12036889;
12070020;
12083487;
12083501;
12095134;
12149215;
12152682;
12172458;
12189027;
12192302;
12270558;
12353085;
12356487;
12408769;
12426405;
12514112;
12529356;
12540946;
12544727;
12603864;
12654807;
12824026;
12871349;
12883669;
12903530;
12920028;
12941032;
12954057;
14597990;
14610342;
14646147;
14675092;
14675093;
14738565;
14750502;
14756558;
14961150;
15016732;
15034795;
15034796;
15039423;
15041276;
15117736;
15154603;
15161741;
15182581;
15213840;
15213854;
15242552;
15252050;
15304041;
15328160;
15467908;
15494427;
15504346;
15522303;
15562024;
15604222;
15607748;
15629154;
15630487;
15664864;
15835921;
15842359;
15860742;
15865421;
15869604;
15892865;
15905465;
15913999;
15935832;
15996056;
16020745;
16113798;
16113838;
16125385;
16182846;
16215234;
16217771;
16236262;
16239598;
16289811;
16324758;
16363246;
16412633;
16453151;
16460932;
16473535;
16487703;
16488980;
16490369;
16507316;
16510984;
16516912;
16529959;
16531802;
16621549;
16634740;
16697385;
16757484;
16794185;
16820938;
16835245;
16839353;
16894464;
16930953;
16937466;
16949034;
16959886;
17008590;
17060476;
17066404;
17137581;
17157899;
17196206;
17200119;
17200762;
17200764;
17237436;
17314141;
17323935;
17324918;
17331567;
17334638;
17347408;
17384202;
17401435;
17456045;
17459125;
17469034;
17470200;
17483700;
17505107;
17536017;
17549302;
17577783;
17586694;
17597988;
17598015;
17663729;
17675290;
17721619;
17726162;
17848177;
17852460;
17883594;
17883595;
17898544;
17900273;
17901245;
17920661;
17922809;
17938822;
17939398;
17947506;
17977694;
17982314;
17991872;
18000605;
18005233;
18019946;
18023707;
18029910;
18031796;
18091328;
18180609;
18278195;
18278454;
18284603;
18292391;
18297283;
18308368;
18310227;
18315555;
18327399;
18363812;
18449421;
18490736;
18495150;
18508060;
18612547;
18640965;
18641355;
18642055;
18645927;
18665396;
18665928;
18677291;
1874730;
18802362;
18835104;
18848323;
18983479;
18983492;
18983503;
18983524;
18989544;
19002040;
19012190;
19027114;
19056482;
19065458;
19091315;
19095643;
19099647;
19105796;
19132232;
19149969;
19167313;
19167713;
19203804;
19219655;
19249541;
19276228;
19290852;
19350119;
19356953;
19359592;
19424642;
19428056;
19483295;
19492160;
19500510;
19515372;
19541671;
19545871;
19558505;
19561489;
19572083;
19578796;
19583819;
19592470;
19597299;
19604541;
19628788;
19631649;
19661141;
19750223;
19795460;
19806259;
19817993;
19828697;
19829668;
19843576;
19856410;
19861441;
19880163;
19904262;
19913121;
19914247;
19923558;
19954621;
19958818;
19966052;
19995406;
20034913;
20045964;
20061396;
20062929;
20076769;
20103969;
20113254;
20138335;
20140262;
20142117;
20149415;
20149924;
20150920;
20153879;
20156644;
20163832;
20171716;
20185792;
20189224;
20224254;
20227257;
20237315;
20237496;
20338779;
20388709;
2040636;
20434002;
20434004;
20434015;
20451919;
20452482;
20524980;
20546120;
20553947;
20589316;
20601186;
20605795;
20628086;
20628259;
20656331;
20673868;
20688968;
20708219;
20708733;
20810696;
20830515;
20846886;
20930172;
20933205;
20978007;
21037076;
21042291;
21059650;
21091668;
21129276;
21149441;
21160057;
21182229;
21186047;
21236471;
21245964;
21248061;
21310953;
21344386;
21367569;
21404058;
21458031;
21464728;
21467727;
21474669;
21483174;
21488215;
21500176;
21502573;
21518473;
21531894;
21535396;
21543928;
21592524;
21605334;
21617868;
21619686;
21621407;
21625939;
21652710;
21690060;
21693061;
21737126;
21762960;
21800004;
21868706;
21934552;
22022598;
22065583;
22066736;
22076613;
22099707;
22115773;
22119392;
22156911;
22178066;
22187432;
22196362;
22212466;
22214850;
22237453;
22340074;
2237820;
22437887;
22461171;
2248955;
22547577;
22652793;
22672593;
22682138;
22683021;
22705067;
2271516;
22771387;
22784289;
22828416;
22964479;
23006890;
23007470;
23029002;
23029190;
23038262;
23065128;
23118232;
23152142;
23195225;
23223577;
23294934;
23325480;
23373413;
23409769;
23434438;
23490466;
23539451;
23578769;
23585459;
23604472;
23621622;
23623171;
23640483;
23666757;
23754313;
23798713;
23801760;
23803674;
24021283;
24094893;
24108579;
24342062;
24378263;
24385191;
24448154;
24470301;
24516673;
24568471;
24759146;
24920554;
24966616;
24998411;
25038529;
25116956;
25163770;
25171777;
25241761;
25242242;
25262106;
25281742;
25312727;
25403348;
25407675;
25425620;
25427791;
25450387;
25463083;
25465717;
25490770;
25596265;
25631539;
25653143;
25665657;
25683933;
25864889;
25881103;
25903973;
25923092;
25931463;
25963480;
26018600;
26025445;
26062685;
26065856;
26136249;
26169722;
26179105;
26221761;
26241501;
26271343;
26281862;
26408917;
26408918;
26408920;
26408922;
26408924;
26408925;
26408927;
26446354;
26471500;
26504080;
26631725;
26658897;
26667361;
26694616;
26715508;
26731648;
26763081;
26765308;
26791271;
26797521;
26967531;
27002259;
2704749;
27057091;
27127202;
27142573;
27207429;
27311950;
27348126;
27427978;
27562418;
27592310;
27599717;
27629739;
27685527;
27721473;
27766025;
27789475;
27807692;
27808345;
27841803;
27926582;
28024455;
28055955;
28076410;
28106852;
28142075;
28151805;
28246677;
28343272;
28419722;
28492698;
28495929;
28521572;
28551673;
28569919;
28729433;
28749986;
28834179;
28841839;
28957360;
28962834;
29032977;
29044292;
29075790;
29217135;
29225295;
29283291;
29427323;
29437288;
29437578;
29452445;
29477147;
29571624;
29658195;
29715083;
29724819;
29787758;
29789989;
29949655;
29976772;
30113368;
30278301;
30408635;
30530119;
30602303;
30698330;
30781507;
31003762;
31654241;
31715000;
31774347;
31796521;
31801825;
32081704;
32152404;
32471327;
32627125;
32665005;
3275472;
32759504;
32896248;
32920807;
33225609;
33893844;
34205482;
34321228;
34884442;
3527261;
6980899;
8065454;
8576248;
8578528;
8940045;
9414278;
9480775;
|
| Motif |
MOTIF 46..48; /note=WKS motif; MOTIF 77..79; /note=WKS motif; MOTIF 190..192; /note=WKS motif |
| Gene Encoded By |
|
| Mass |
33,068 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|