| IED ID | IndEnz0002013531 |
| Enzyme Type ID | protease013531 |
| Protein Name |
Snake venom serine protease IVa SVSP EC 3.4.21.- Basic proteinase IVa Fragment |
| Gene Name | |
| Organism | Cerastes cerastes (Horned desert viper) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Viperinae (vipers) Cerastes Cerastes cerastes (Horned desert viper) |
| Enzyme Sequence | VIGGAEENINEHRSL |
| Enzyme Length | 15 |
| Uniprot Accession Number | Q7LZF4 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inactivated by p-APMSF, leupeptin, iodoacetamide, protein kinase C inhibitor, phosphatase inhibitor, ATP and PGE1. Is insensitive to acetylsalicylic acid, ADP scavenger system, protein kinase A inhibitor and hirudin. {ECO:0000269|PubMed:7612660}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Snake venom serine protease that potently induces platelet aggregation. Its aggregatory activity is partially inhibited by monoclonal antibodies against GPIb and the thrombin receptor. Its ability to induce intracellular Ca(2+) release is blocked by pretreating platelets with thrombin. Hydrolyzes thrombin chromogenic substrate CBS 34.47, but shows very weak coagulant activity. Can hydrolyze fibrinogen alpha-chains. {ECO:0000269|PubMed:7612660}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Non-terminal residue (1) |
| Keywords | Direct protein sequencing;Hemostasis impairing toxin;Hydrolase;Platelet aggregation activating toxin;Protease;Secreted;Serine protease;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 1,638 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |