| IED ID | IndEnz0002013624 |
| Enzyme Type ID | protease013624 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase 37 EC 3.4.19.12 Deubiquitinating enzyme 37 Ubiquitin thioesterase 37 Ubiquitin-specific-processing protease 37 |
| Gene Name | usp37 zgc:152882 zgc:153999 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MAAAVPRLTSGGAVRIRIRCGELGTTKWREGVIEIQERDNKINLLVKFNSGGAPRVFQLSHNVKSVSWFQTHGPNRMTLTLKDSCIVMMDKLNMLVAKKMKEYLETVKLGKPAVFKTNQGSASFGLVLGNRTAQNDSGLSPSDKQSAPRRSSLDSREDSTPRKPLGSPSRVTSTPARGSLSEIRSEKRKRLMNSDGDLTEDYPKENDSSSNNKAITDSSRKFLLSCKDKLKQSEENRASAPHTPAPLQPTSFYGSRTGAKDYTQTHSFLDRPSSTGSCPSAKRSLVLPNHSTPFKKVRPTLDYGGWNKPRPSVLAQPQPPLQGFSNLGNTCYMNAILQSLFSLPSFSNDLLKQGIPWKRVPINALLRRFAHLLAKKDISPPEVKKDLLRRVKNAISSTAERFSGYMQNDAHEFLSQCLDQLKEDVEKINKSWKNEPSAWDEPQSTRLADEVDTSRIYTCPVTVNMEFEVQHTITCKSCGEVVLKREQFNDLSIDLPRRRKTLPMRSIQDSLDLFFRMEEIEYSCEKCSGKAATVSHKFSRLPRVLILHLKRYSYNTQLSLNSKLGQQVLIPKYLTLLSHCTDATRSPLSLGWSAQNALSRTLKISQSVNSSTLRRASQRPESSGSVLCDSDSDEELVRKVARKHHPDDDRADELQQHHPHAAVEQSEFNGINDEEMLAAVLEMSRHDTSLCAGPDEEPSSSPDTGFGDADAHDLTQHLELLDAEKQPTDALESLDLTMDENKENQTPDGLQGELDWVQQYSLEQEREEQELQQALAQSLQEQEAREMREDDDLKRATELSLQEFNNSLPELLCSDEDSGNEDGLDMEYSEAEAEELKKNAETGELPNSFRLISVVSHIGSSSSSGHYISDVYDMKKQSWLTYNDLDVSRTQESTVQRDRDRSGYIFFYMHKDVFEELSELEKAGVNTDGGRTVLQPL |
| Enzyme Length | 937 |
| Uniprot Accession Number | E7F6T8 |
| Absorption | |
| Active Site | ACT_SITE 331; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 866; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; |
| DNA Binding | |
| EC Number | 3.4.19.12 |
| Enzyme Function | FUNCTION: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of APC/C target proteins, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (6); Domain (4); Motif (6); Region (4); Sequence conflict (18) |
| Keywords | Cell cycle;Cell division;Hydrolase;Mitosis;Protease;Reference proteome;Repeat;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20040115; 28450118; |
| Motif | MOTIF 38..40; /note=KEN box 1; /evidence=ECO:0000250; MOTIF 76..84; /note=D-box 1; /evidence=ECO:0000250; MOTIF 101..110; /note=D-box 2; /evidence=ECO:0000250; MOTIF 162..170; /note=D-box 3; /evidence=ECO:0000250; MOTIF 204..206; /note=KEN box 2; /evidence=ECO:0000250; MOTIF 742..744; /note=KEN box 3; /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 105,264 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |