| IED ID | IndEnz0002013629 |
| Enzyme Type ID | protease013629 |
| Protein Name |
Venom metalloproteinase antarease-like TfasMP_A VMPA EC 3.4.24.- |
| Gene Name | |
| Organism | Tityus fasciolatus (Central Brazilian scorpion) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Tityus Tityus fasciolatus (Central Brazilian scorpion) |
| Enzyme Sequence | DDCIVVEYYIVTDSAFTKRFKSNSALTKYVTVMFTGVQNLMDTLELGIGVRLLGVTAFNEETEPSFIIDNLISGPPEAFDPDVLITAMSEYYCNHQIGLAKNTDLIFLITARGMGDPREDGTVDINTAGIANSAGVYKPCLKAGVATDDSDYNERVDTLAHESVHLLGSPHDGEGPDQVSLEGSPGAANCPAKAGYIMGNRNDKNKYKFSPCTKKCVEYLLSKPAASCIFEQCSGF |
| Enzyme Length | 236 |
| Uniprot Accession Number | V9Z7R6 |
| Absorption | |
| Active Site | ACT_SITE 162; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by EDTA. {ECO:0000250}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Acts as a metalloprotease. Penetrates intact tissue and specifically cleaves the vesicle-associated membrane protein 2 (VAMP2) (part of the SNARE complex) involved in pancreatic secretion, thus disrupting the normal vesicular traffic (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Domain (1); Metal binding (3) |
| Keywords | Calcium;Disulfide bond;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Toxin;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Contains several disulfide bonds. {ECO:0000305}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 25,505 |
| Kinetics | |
| Metal Binding | METAL 161; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 165; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276; METAL 171; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU00276 |
| Rhea ID | |
| Cross Reference Brenda |