| IED ID | IndEnz0002013674 |
| Enzyme Type ID | protease013674 |
| Protein Name |
Teneurin-1 Ten-1 Protein Odd Oz/ten-m homolog 1 Tenascin-M1 Ten-m1 Teneurin transmembrane protein 1 Cleaved into: Ten-1 intracellular domain IDten-1 Ten-1 ICD ; Teneurin C-terminal-associated peptide TCPA-1 Ten-1 extracellular domain Ten-1 ECD |
| Gene Name | Tenm1 Odz1 Tnm1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MEQTDCKPYQPLSKVKHEMDLAYTSSSDESEDGRKPRQSFNSRETLHEYNQELRRNYNSQSRKRKDVEKSTQEIEFCETPPTLCSGYHTDMHSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAPADSAQDMQSSPHNQFTFRPLPPPPPPPHACTCARKPPPTVDSLQRRSMTTRSQPSPAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFGLTWQLQPVGQIYANGISNGNPGTESMDTTYSPIGGRVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKSSDDIQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRNGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSSHGICVKGECHCSTGWGGVNCETPLPICQEQCSGHGTFLLDTGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCAEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNIVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYVSPLCQGSPDPLDLIQQSQPLFSQHTSRLFYDRIKFLIGKDSTHVVPQDISFDSRRACVIRGQVVAVDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVVLIFDRSPFLSEKRTLWLPWNQFIVVEKVIMQRIVADAPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVSVEGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYEMCPEFILWEQRTVVLQGFEMDASNLGGWSLNKHHIFNPQSGIIHKGNGENMFISQQPPVIATIMGNGHQRSVACTNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELRNRDTRHSTSPAHKYYLAMDPMSESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGKASEASLNSPRGITVDRHGFIYFVDGTMIRRIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVSHSGLLFIAETDERKVNRIQQVTTNGEISIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISKNQAHLNDMNLYEIASPADQELYQFTVNGTHLHTMNLITRDYVYNFTYNAEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVALDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVSPDGSLRVTFASGMEINLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSIDFDHMTRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQSDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTKQARLSEILYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGLVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFNANGQVIEVQYEILKAIAYWMTIQYDNMGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKIQWRYSYDLNGNINLLSHGNSARLTPLRYDLRDRITRLGEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKVSGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLANPIRVTHLYNHTSAEITSLYYDLQGHLIAMELSSGEEYYVACDNMGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFEVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIWKQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIGTWLELFGFQLHNVLPGFPKPELENMELTYELLQLQTKTQEWDPGKMILGIQCELQKQLRNFISLDQLPMTPQYNEGRCLEGGKQPRFAAVPSVFGKGIKFAIKEGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNIRYGTTVEEEKNHVLEMARQRAVAQAWTQEQRRLQEGEEGTRVWTEGEKQQLLGTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR |
| Enzyme Length | 2731 |
| Uniprot Accession Number | Q9WTS4 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). {ECO:0000250}.; FUNCTION: [Teneurin C-terminal-associated peptide]: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking. {ECO:0000269|PubMed:15710242, ECO:0000269|PubMed:17174479, ECO:0000269|PubMed:17644218, ECO:0000269|PubMed:17900539, ECO:0000269|PubMed:18082275, ECO:0000269|PubMed:19428634, ECO:0000269|PubMed:20883474, ECO:0000269|PubMed:21411044, ECO:0000269|PubMed:22209827, ECO:0000269|PubMed:22698694}.; FUNCTION: [Ten-1 intracellular domain]: Induces gene transcription activation. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (3); Compositional bias (2); Disulfide bond (22); Domain (9); Glycosylation (14); Modified residue (4); Motif (2); Region (2); Repeat (28); Site (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Cell membrane;Cleavage on pair of basic residues;Cytoplasm;Cytoskeleton;Disulfide bond;EGF-like domain;Glycoprotein;Membrane;Neuropeptide;Nucleus;Phosphoprotein;Reference proteome;Repeat;Repressor;Secreted;Stress response;Transcription;Transcription regulation;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:23026563}; Single-pass membrane protein {ECO:0000269|PubMed:23026563}. Note=Colocalizes with isoform 2 at the plasma membrane.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Cell membrane. Secreted {ECO:0000305}. Note=Transported to the cell membrane and probably secreted to function as an autocrine or paracrine signaling molecule. The lack of a hydrophobic segment sequence suggests that isoform 2 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.; SUBCELLULAR LOCATION: [Ten-1 intracellular domain]: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.; SUBCELLULAR LOCATION: [Teneurin C-terminal-associated peptide]: Nucleus {ECO:0000305}. Cytoplasm. Cell membrane. Note=Colocalizes with isoform 1 at the plasma membrane. Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus. |
| Modified Residue | MOD_RES 105; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:21183079; MOD_RES 109; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:21183079; MOD_RES 116; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:21183079; MOD_RES 2586; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9UKZ4 |
| Post Translational Modification | PTM: [Isoform 2]: Once secreted, may also be cleaved to give rise to the TCAP-1 form. {ECO:0000269|PubMed:23026563}.; PTM: [Teneurin C-terminal-associated peptide]: Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may generate 11.9 and 4.7 kDa bioactive peptides. {ECO:0000269|PubMed:23026563}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10341219; 12466851; 14681479; 16919471; 21651764; 21677750; 27040985; 27720483; 27798109; 28558017; |
| Motif | MOTIF 62..65; /note=Nuclear localization signal (NLS); /evidence=ECO:0000250; MOTIF 290..297; /note=Required for interaction with SORBS1 (Ten-1 ICD form); /evidence=ECO:0000250 |
| Gene Encoded By | |
| Mass | 305,795 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |