| IED ID | IndEnz0002013679 |
| Enzyme Type ID | protease013679 |
| Protein Name |
Tryptase-2 EC 3.4.21.59 |
| Gene Name | |
| Organism | Ovis aries (Sheep) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Caprinae Ovis Ovis aries (Sheep) |
| Enzyme Sequence | MLHLLALALLLSLVSAAPAPGQALQRSGIIGGKEAPGSRWPWQVSLRVRDQYWRHQCGGSLIHPQWVLTAAHCIGPELQEPSDFRVQLREQHLYYQDRLLPISRVIPHPHYYMVENGADIALLQLEEPVSISRHVQPVTLPPASETFPPESQCWVTGWGDVDNGRPLPPPYPLKQVKVPIVENSVCDWKYHSGLSTDYSVPIVQEDNLCAGDGGRDSCQGDSGGPLVCKVNGTWLQAGVVSWGDGCAKPNRPGIYTRITSYLDWIHQYVPQEP |
| Enzyme Length | 273 |
| Uniprot Accession Number | Q9XSM2 |
| Absorption | |
| Active Site | ACT_SITE 72; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 119; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 222; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.; EC=3.4.21.59; |
| DNA Binding | |
| EC Number | 3.4.21.59 |
| Enzyme Function | FUNCTION: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (4); Domain (1); Glycosylation (1); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 30,288 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.59; |