IED Industry Enzyme Database

Detail Information for IndEnz0002013709
IED ID IndEnz0002013709
Enzyme Type ID protease013709
Protein Name Baculoviral IAP repeat-containing protein 5
Apoptosis inhibitor 4
Apoptosis inhibitor survivin
Gene Name BIRC5 API4 IAP4
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
Enzyme Length 142
Uniprot Accession Number O15392
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:16291752, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:20929775, ECO:0000269|PubMed:21364656, ECO:0000269|PubMed:21536684, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735, ECO:0000269|PubMed:9859993}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (6); Beta strand (5); Chain (1); Helix (7); Metal binding (4); Modified residue (11); Mutagenesis (22); Natural variant (1); Repeat (1); Sequence conflict (3); Site (1); Turn (3)
Keywords 3D-structure;Acetylation;Alternative splicing;Apoptosis;Cell cycle;Cell division;Centromere;Chromosome;Chromosome partition;Cytoplasm;Cytoskeleton;Kinetochore;Metal-binding;Microtubule;Mitosis;Nucleus;Phosphoprotein;Protease inhibitor;Reference proteome;Repressor;Thiol protease inhibitor;Transcription;Transcription regulation;Ubl conjugation;Zinc
Interact With Q92870-2; P05067; P05067-2; O14965; Q96GD4; Q9UQB9; Q14457; Itself; Q15834; Q53HL2; P06493; Q14203-5; Q9NR28; Q86XJ1; Q8TB36; P42858; Q9NQS7; A0A0C4DGV4; Q96CV9; Q7Z412; Q9BXM7; P62826; P37840; Q13148; P09936; O14980; Q96GD4; Itself; Q53HL2; Q96GD4; O15392-1; Q53HL2
Induction INDUCTION: Up-regulated by COMP. {ECO:0000269|PubMed:17993464}.
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Nucleus {ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:21364656}. Chromosome {ECO:0000269|PubMed:14610074}. Chromosome, centromere {ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:16322459}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11084331}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11084331}. Midbody {ECO:0000269|PubMed:15665297}. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody (PubMed:11084331). Colocalizes with AURKB at mitotic chromosomes (PubMed:14610074). Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (PubMed:20826784). {ECO:0000250|UniProtKB:E3SCZ8, ECO:0000269|PubMed:11084331, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:20826784}.
Modified Residue MOD_RES 20; /note="Phosphoserine; by AURKC"; /evidence="ECO:0000269|PubMed:27332895"; MOD_RES 23; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:20826784"; MOD_RES 34; /note="Phosphothreonine; by CDK1 and CDK15"; /evidence="ECO:0000269|PubMed:11069302, ECO:0000269|PubMed:24866247, ECO:0007744|PubMed:18691976"; MOD_RES 48; /note="Phosphothreonine; by CK2; in vitro"; /evidence="ECO:0000269|PubMed:21252625"; MOD_RES 90; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:20826784"; MOD_RES 110; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:20826784"; MOD_RES 112; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:20826784"; MOD_RES 115; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:20826784"; MOD_RES 117; /note="Phosphothreonine; by AURKB"; /evidence="ECO:0000269|PubMed:14610074"; MOD_RES 121; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:20826784"; MOD_RES 129; /note="N6-acetyllysine"; /evidence="ECO:0000269|PubMed:20826784"
Post Translational Modification PTM: Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting. {ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:24793696}.; PTM: In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes (PubMed:14610074). Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities (PubMed:21252625). Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity (PubMed:24866247). Phosphorylation at Ser-20 by AURKC is critical for regulation of proper chromosome alignment and segregation, and possibly cytokinesis. {ECO:0000269|PubMed:11069302, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:21252625, ECO:0000269|PubMed:24866247, ECO:0000269|PubMed:27332895}.; PTM: Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation. {ECO:0000269|PubMed:20826784}.
Signal Peptide
Structure 3D NMR spectroscopy (1); X-ray crystallography (24)
Cross Reference PDB 1E31; 1F3H; 1XOX; 2QFA; 2RAW; 2RAX; 3UEC; 3UED; 3UEE; 3UEF; 3UEG; 3UEH; 3UEI; 3UIG; 3UIH; 3UII; 3UIJ; 3UIK; 4A0I; 4A0J; 4A0N; 6SHO; 6YIE; 6YIF; 6YIH;
Mapped Pubmed ID 10867011; 11024045; 11069780; 11081627; 11120780; 11181178; 11404481; 11509732; 11712083; 11714700; 11728454; 11773702; 11804586; 11821157; 11844831; 11861764; 11875736; 11877677; 11888845; 11925104; 12006501; 12073047; 12085263; 12115583; 12119561; 12133447; 12143224; 12168867; 12174930; 12194817; 12235242; 12363043; 12374680; 12388702; 12393476; 12419797; 12510154; 12517802; 12556969; 12569609; 12600988; 12609713; 12643601; 12654446; 12678716; 12709681; 12719470; 12794243; 12805209; 12833149; 12854136; 12883703; 12885482; 12926071; 12963850; 14523021; 14527689; 14581472; 14583779; 14597555; 14597622; 14614132; 14676801; 14699067; 14730319; 14734714; 14988404; 15077160; 15085137; 15126108; 15138717; 15139971; 15148334; 15149158; 15195112; 15280424; 15294091; 15309737; 15326475; 15334064; 15334693; 15339662; 15383173; 15456784; 15457550; 15477601; 15489959; 15512811; 15531913; 15541727; 15547736; 15569667; 15611790; 15623349; 15628841; 15637054; 15655550; 15670305; 15685548; 15688031; 15709157; 15723797; 15729715; 15735703; 15737063; 15743529; 15802787; 15809755; 15817155; 15829320; 15829330; 15831281; 15870931; 15882878; 15896468; 15916722; 15917996; 15923164; 15924721; 15928668; 15936846; 15938719; 15943789; 15950906; 15986442; 15991282; 16026775; 16048634; 16055565; 16108013; 16123317; 16142334; 16142363; 16171786; 16173017; 16202147; 16211215; 16211302; 16254145; 16364925; 16372125; 16375115; 16375117; 16397018; 16404364; 16407408; 16470228; 16510571; 16512495; 16516635; 16525632; 16525657; 16529600; 16534839; 16541025; 16552335; 16571674; 16595680; 16608879; 16622419; 16622420; 16644787; 16671090; 16714396; 16732934; 16761316; 16773218; 16807248; 16825985; 16826583; 16847054; 16850112; 16873289; 16950794; 17008426; 17012855; 17015676; 17018890; 17030981; 17038538; 17045968; 17077982; 17084966; 17087938; 17095626; 17098350; 17099693; 17108713; 17124585; 17127378; 17128412; 17129783; 17143520; 17167759; 17170079; 17203351; 17219991; 17225522; 17255535; 17274640; 17283539; 17285125; 17289902; 17304504; 17328950; 17337592; 17341657; 17353931; 17357516; 17361097; 17376603; 17393113; 17441339; 17451195; 17457057; 17464868; 17505517; 17509581; 17533050; 17534699; 17536304; 17543072; 17548900; 17559540; 17569112; 17582222; 17609820; 17612487; 17613533; 17616652; 17624454; 17633470; 17634026; 17635796; 17638911; 17641414; 17656368; 17666323; 17672950; 17680529; 17681274; 17687492; 17693049; 17704744; 17706282; 17714426; 17718383; 17785436; 17805549; 17828494; 17828496; 17828507; 17877643; 17879398; 17881355; 17905101; 17927889; 17943598; 17959540; 17961802; 17962949; 17965335; 17967504; 17982126; 18027854; 18032822; 18035418; 18048012; 18055328; 18057009; 18058462; 18069771; 18079751; 18089792; 18097444; 18154598; 18171606; 18181175; 18192073; 18206228; 18226337; 18227733; 18242580; 18243099; 18250050; 18251132; 18251156; 18251581; 18266976; 18278445; 18298903; 18301249; 18316606; 18327814; 18332262; 18334114; 18336724; 18336887; 18353781; 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19397802; 19405109; 19421758; 19423183; 19428321; 19439469; 19451595; 19469654; 19472128; 19483728; 19497660; 19500507; 19506533; 19585499; 19605357; 19615253; 19621386; 19624872; 19628339; 19632843; 19636556; 19639203; 19664395; 19676105; 19679061; 19705503; 19716375; 19724852; 19728912; 19728914; 19729377; 19756737; 19763917; 19767411; 19778801; 19781773; 19787275; 19806913; 19832036; 19840459; 19885569; 19887369; 19895735; 19895744; 19903782; 19913527; 19921309; 19933689; 19939880; 19949374; 19951584; 19956893; 19965387; 20010504; 20011512; 20019839; 20027603; 20028510; 20041268; 20050981; 20056675; 20057973; 20072652; 20094073; 20100132; 20101202; 20104682; 20126979; 20128283; 20178473; 20181247; 20193113; 20193400; 20195727; 20235790; 20236666; 20306657; 20346215; 20357690; 20360068; 20367605; 20368071; 20372866; 20398291; 20401641; 20403046; 20406824; 20427271; 20430742; 20444731; 20453000; 20470195; 20493732; 20501415; 20503268; 20506498; 20515940; 20524087; 20551096; 20596624; 20597995; 20627293; 20638385; 20663916; 20668868; 20682707; 20698994; 20716114; 20717727; 20724919; 20728447; 20735270; 20735841; 20798131; 20800603; 20807887; 20819778; 20822926; 20842728; 20851637; 20862566; 20868995; 20881643; 20882051; 20929126; 20939430; 20957442; 20959405; 20978324; 20979750; 21034499; 21041181; 21048031; 21051298; 21055155; 21057000; 21062054; 21074309; 21082354; 21083600; 21092276; 21093004; 21106262; 21108736; 21130077; 21148584; 21154810; 21156966; 21158719; 21159887; 21161671; 21187067; 21198263; 21211287; 21215029; 21220185; 21223797; 21279308; 21292023; 21296634; 21304814; 21309483; 21312234; 21330050; 21342791; 21351527; 21355309; 21358596; 21362215; 21364662; 21367753; 21385904; 21397845; 21402055; 21415216; 21424389; 21431279; 21443519; 21447816; 21470426; 21516372; 21518489; 21526486; 21538024; 21552210; 21554500; 21565982; 21569999; 21572400; 21585553; 21611748; 21612579; 21613637; 21633298; 21634118; 21674243; 21689689; 21695980; 21705450; 21718681; 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22848370; 22858571; 22885700; 22886454; 22925504; 22930255; 22935455; 22936565; 22957790; 22961763; 22968628; 22981350; 22996285; 23028610; 23030305; 23041974; 23042483; 23053158; 23065255; 23084269; 23087365; 23091600; 23097134; 23106581; 23124118; 23126236; 23131769; 23143666; 23146905; 23152437; 23161837; 23167185; 23168152; 23172665; 23176035; 23185410; 23219440; 23232114; 23244104; 23251006; 23254641; 23254909; 23258739; 23280017; 23281010; 23296940; 23310986; 23317219; 23323858; 23324341; 23325045; 23333752; 23338618; 23340171; 23358177; 23358691; 23368531; 23380758; 23405077; 23405201; 23414714; 23444076; 23449974; 23467576; 23477121; 23479154; 23494669; 23504337; 23564498; 23572266; 23580032; 23581553; 23611357; 23613251; 23618862; 23624914; 23640047; 23643942; 23645041; 23677479; 23690235; 23728352; 23729541; 23732815; 23747271; 23749114; 23755220; 23812937; 23826993; 23828577; 23847060; 23856250; 23858797; 23883402; 23898122; 23924925; 23936532; 23938875; 23948878; 23979427; 24077840; 24083380; 24096544; 24097101; 24117205; 24127439; 24128853; 24133585; 24165223; 24197699; 24199968; 24204662; 24213373; 24213518; 24223763; 24223792; 24233638; 24235270; 24239173; 24294379; 24303016; 24317109; 24325949; 24337012; 24338338; 24338523; 24386184; 24387108; 24425325; 24440709; 24448704; 24448706; 24460358; 24478433; 24495510; 24508259; 24519067; 24556686; 24563335; 24571573; 24596368; 24615109; 24618734; 24620748; 24636883; 24647137; 24648609; 24662134; 24676140; 24722794; 24726064; 24735609; 24743777; 24786601; 24793695; 24852427; 24852932; 24886358; 24886421; 24886669; 24891298; 24920238; 24930483; 24935470; 24945990; 24946930; 24961465; 24972968; 24996542; 25008566; 25018047; 25022384; 25028191; 25040987; 25046253; 25050620; 25069511; 25090821; 25106503; 25107550; 25129311; 25169544; 25177958; 25218447; 25241761; 25248821; 25261663; 25288231; 25294423; 25317803; 25333812; 25337230; 25344020; 25374237; 25392106; 25429620; 25471003; 25473903; 25480498; 25537090; 25577253; 25598934; 25605253; 25607650; 25635055; 25640185; 25661346; 25677909; 25701406; 25707849; 25726084; 25763854; 25769404; 25771974; 25789526; 25808836; 25810016; 25816072; 25824761; 25867400; 25875800; 25889770; 25890196; 25895606; 25896962; 25900794; 25910412; 25917317; 25928399; 25948791; 25964579; 25966084; 25973061; 26002465; 26016480; 26017879; 26022098; 26043753; 26080853; 26093789; 26112839; 26118178; 26122233; 26125713; 26148234; 26183563; 26191195; 26198101; 26227487; 26245993; 26261483; 26261647; 26268608; 26271669; 26318298; 26327128; 26352384; 26356696; 26392111; 26408642; 26419626; 26420684; 26442524; 26450645; 26470725; 26497847; 26540052; 26557682; 26595675; 26600399; 26614845; 26647806; 26648308; 26651826; 26677013; 26679694; 26681053; 26690822; 26708654; 26718331; 26718651; 26723509; 26755645; 26771605; 26815661; 26823716; 26828978; 26832409; 26896649; 26944315; 26969755; 26978233; 26995334; 27055667; 27079211; 27090386; 27097943; 27166029; 27177222; 27235693; 27246243; 27322712; 27350406; 27371848; 27372966; 27378628; 27399126; 27400093; 27411340; 27411378; 27420945; 27423588; 27430728; 27473264; 27489375; 27531889; 27539959; 27581819; 27602754; 27663628; 27715398; 27748828; 27764228; 27798120; 27803511; 27806337; 27865841; 27866460; 27915033; 27978829; 28011476; 28039474; 28095864; 28178644; 28193315; 28214203; 28260087; 28319412; 28319413; 28328831; 28337018; 28346726; 28365965; 28384094; 28430038; 28446541; 28476028; 28476037; 28509321; 28518147; 28655776; 28713892; 28751665; 28803837; 28845553; 28849238; 28852723; 28883406; 28949095; 28950390; 28952057; 28953948; 28981528; 29089085; 29113504; 29180609; 29233639; 29270761; 29277888; 29282022; 29311669; 29328641; 29330624; 29391151; 29416000; 29473241; 29491110; 29517199; 29522718; 29578160; 29596838; 29604934; 29605299; 29625788; 29631694; 29678577; 29740686; 29767242; 29795564; 29802019; 29807222; 29848705; 29893319; 29901157; 29913237; 29917189; 29956756; 29956779; 29961070; 29989646; 30003758; 30010107; 30061219; 30075571; 30086460; 30106446; 30128768; 30226700; 30241553; 30249893; 30275230; 30323195; 30351173; 30456501; 30465472; 30483758; 30489176; 30537730; 30641849; 30664711; 30683476; 30715796; 30722117; 30736319; 30765238; 30774747; 30776886; 30834699; 30876863; 30880759; 30948431; 30969080; 31020660; 31031231; 31053526; 31093306; 31104397; 31113740; 31128011; 31165868; 31250439; 31315909; 31322187; 31428968; 31438837; 31441344; 31539134; 31591437; 31601255; 31612776; 31638931; 31642557; 31663299; 31692460; 31711057; 31718698; 31786858; 31809840; 31861751; 31893572; 31929540; 31929744; 31948306; 31959045; 31991041; 32019552; 32094363; 32107072; 32152425; 32279998; 32322338; 32356865; 32468587; 32546857; 32599467; 32664056; 32709750; 32719269; 32729225; 32814079; 32825933; 32945459; 32951213; 33153400; 33171188; 33196129; 33221541; 33247694; 33431968; 33472892; 33494811; 33513976; 33518654; 33686072; 33710603; 33836600; 33845641; 33863308; 33888009; 33914777; 34014801; 34082009; 34096679; 34100981; 34112092; 34257556; 34278505; 34438346; 34517565; 34580516; 7898939; 9874564;
Motif
Gene Encoded By
Mass 16,389
Kinetics
Metal Binding METAL 57; /note="Zinc"; /evidence="ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA"; METAL 60; /note="Zinc"; /evidence="ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA"; METAL 77; /note="Zinc"; /evidence="ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA"; METAL 84; /note="Zinc"; /evidence="ECO:0000269|PubMed:17956729, ECO:0007744|PDB:2QFA"
Rhea ID
Cross Reference Brenda