| IED ID | IndEnz0002013713 |
| Enzyme Type ID | protease013713 |
| Protein Name |
Calpain-D EC 3.4.22.- Calcium-activated neutral proteinase D CANP D Small optic lobes protein |
| Gene Name | sol CalpD CG1391 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MGTISSVLQWSCTKCNTINPTESLKCFNCGTVRKVFPQQQQQQHRSSSITASWTADDALEQEQAEKGQERDKEKGRAAVARSEYKHVYKSLLRGCLKRPQRNSQNLPANCVDCEDTRKYIKSSIELYRHFSNPALNRRWVCHACGTDNSSVTWHCLICDTVSYLAPIYKDAIAADRGQDLAGSLGNRGELLAADHSHPHHHHHYLHQELEEQHQHQLHSQHLHKRHLKGRSASGSGSGPGSGSGLRRTQSLSTAIDKSASGRSCHICYANNQSKDIFNLPQIKPAPQLTGIPPVAACSNSRFAIANDTFCRRKQNNNNKNQNHKVVRESGAKRKYNFTITTLSRSAAKDAGHGQMKPLRQVVNLNLNLQQEPQQKSPANPQQLQRKTQREPAAVSMNPTQFTIPRNGVFIAVNEWSEPMASSSSVSSSSNHHHHHHSNSNSNSSGNSNIINNNSSSSSGSNKLYENECVALAQQQLRAAAAQAAQAAATAVAIASSPSAKAMAEPAPTATMPIYAQVNKQHKLKKKQQIASESQTNNNTGSGEIADAVSESLTAGLGTSTDGSGEASESESQVEEHSIYAKVWKGPRKATESKIMHDPGSSSRLSGAASAAAGTASAGAIAAAVGAAAASRHDNKTQLGNGSRSKMWICIKCSYAYNRLWLQTCEMCEAKAEQQQQQLQLQQQQQQQQQHHHHHLQQQQAEAPRDEPWTCKKCTLVNYSTAMACVVCGGSKLKSISSIEDMTLRKGEFWTCSHCTLKNSLHSPVCSACKSHRQPQLSMAMEAVRERPDGQSYEEQDAAAVGGGGGSAHQSGANEVKAPTALNLPLTSVALPMPMLQLPTSTAAGLRGSRSPSPRMQLLPSLQQQRNSSSSGAIPKRHSTGGSIVPRNISIAGLANYNLQQGQGVGSASVVSASGAGSGAGAVGASTSTKKWQCPACTYDNCAASVVCDICSSPRGLASAVLGEALGRKSVRVALTPADIRQESKLMENLRQLEETEALTKWQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQGAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVYSQAKRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQGHRLLKLRNPWGHYSWRGDWSDDSSLWTDDLRDALMPHGASEGVFWISFEDVLNYFDCIDICKVRSGWNEVRLQGTLQPLCSISCVLLTVLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHSKRQVRGFVGCHKMLERDIYLLVCLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQISPSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVENRHENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRGLHDWGPPGATHCPPIENVHGLHAPRLIT |
| Enzyme Length | 1594 |
| Uniprot Accession Number | P27398 |
| Absorption | |
| Active Site | ACT_SITE 1079; /evidence=ECO:0000250; ACT_SITE 1245; /evidence=ECO:0000250; ACT_SITE 1265; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Has a role in eye development. {ECO:0000269|PubMed:1714593}.; FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (3); Chain (1); Compositional bias (5); Domain (1); Erroneous gene model prediction (1); Modified residue (1); Region (8); Sequence conflict (9); Zinc finger (6) |
| Keywords | Alternative splicing;Developmental protein;Hydrolase;Metal-binding;Phosphoprotein;Protease;Reference proteome;Repeat;Sensory transduction;Thiol protease;Vision;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 250; /note=Phosphoserine; /evidence=ECO:0000269|PubMed:18327897 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11086999; 11264413; 11389437; 14605208; 15382138; 1618027; 1634996; 16592962; 17166275; 18039869; 18838607; 20220848; 20371351; 20670829; 2108664; 2113574; 22494833; 22884528; 23071443; 23722427; 23819581; 24655073; 2499511; 25687947; 26220523; 26370122; 30705102; 3097291; 3104567; 4020527; 414732; 6409413; 6428950; 7823949; 8096642; 8163008; 8276996; 8331341; 8552658; 8640222; 8643671; 9396712; 9454557; 9520435; 9571143; 9754871; |
| Motif | |
| Gene Encoded By | |
| Mass | 174,313 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.B35; |