| IED ID | IndEnz0002013719 |
| Enzyme Type ID | protease013719 |
| Protein Name |
Immune inhibitor A EC 3.4.24.- |
| Gene Name | ina |
| Organism | Bacillus thuringiensis subsp. alesti |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus cereus group Bacillus thuringiensis Bacillus thuringiensis subsp. alesti |
| Enzyme Sequence | MKDAKADTKEKLNQPATGTPAATGPVKGGLNGKVPTSPAKQKAYNGDVRKDKVLVLLVEYADFKHNNIDKEPGYMYSEDFNKEHYEKMLYGDEPFALEDGSKIETFKQYYEEQSGGSYTVDGTVTKWLTVPGKAADYGADAATGHDNKGPKGPRDLVKDALKAAVDSGLDLSQFDQFDQYDVNGDGNQNQPDGLIDHLMIIHAGVGQEAGGGKLGDDAIWSHRWTVGPKPFAIEGTQAKVPYWGGKMAAFDYTIEPEDGAVGVNAHEYGHDLGLPDEYDTDYTGHGEPIQAWSVMSGGTWAGKIAGTTPTSFSPQNKEFFQKTIGGNWANIVEVDYEKLNKGIGLATYLDQSVTKSNRPGMIRVNLPDKDVKTIRPAFGKQYYYSTKGDNLHTTLETPLFDLTNATNAKFDFKSLYEIEAEYDFLEVHAVTEDGQKTLIERLGEKANSGNAEATNGKWIDKSYDLSQFKGKKVKLTFEYITDGGLALNGGLLDNASLTVDGKVTFSDDAEGTPQLKLDGFVVSSGTEKKKHNYYVEWRNHTGSDSALKFARGPEYNSGMVVWYADSAYADNWVGLHPGHGFLGVVDSHPEAIVGTLNGKPTIDSSTRFQIADAAFSFDKTPAWKVVSPTRGTYTYDGLAGVAKFDDSKTYINQQIPDAGRILPKLGLKFEVVGQADDNSAGAVRLYR |
| Enzyme Length | 687 |
| Uniprot Accession Number | P23382 |
| Absorption | |
| Active Site | ACT_SITE 267; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Neutral metalloprotease that is secreted to degrade antibacterial proteins produced by the insect host for its defense (attacins and cecropins). Probably degrades some unknown crucial protein(s) too, since it is toxic when injected to insect larvae. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Metal binding (2); Propeptide (1); Region (1); Signal peptide (1) |
| Keywords | Calcium;Direct protein sequencing;Hydrolase;Metal-binding;Metalloprotease;Protease;Secreted;Signal;Virulence;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..?25; /note=Or 32 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 75,010 |
| Kinetics | |
| Metal Binding | METAL 266; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 270; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |