| IED ID | IndEnz0002013741 |
| Enzyme Type ID | protease013741 |
| Protein Name |
Metacaspase-5 EC 3.4.22.- TcMCA5 |
| Gene Name | MCA5 Tc00.1047053510759.160 |
| Organism | Trypanosoma cruzi (strain CL Brener) |
| Taxonomic Lineage | cellular organisms Eukaryota Discoba Euglenozoa Kinetoplastea (kinetoplasts) Metakinetoplastina Trypanosomatida Trypanosomatidae Trypanosoma Schizotrypanum Trypanosoma cruzi Trypanosoma cruzi (strain CL Brener) |
| Enzyme Sequence | MDLLLGVLSSGILQNALPFVAGVGRVKRPKRVKLEEAFREAHLCRPVIPYRAPTPYTGGRVKALFVGINYTGTRNKLSGCVNDVRQMLGTLQRIQFPISECCILVDDMRFPNFTALPTRENIIKHMAWLVHDVRPGDVLFFHYSGHGTETKAERDSEELYDQCLVPLDYQVQGAILDDDLFELLVKGLPAGVRMTAVFDCCHSASLLDLPFAFVGNNNFYSGGRHEMRKVRANNFSMGDVVVFSGCDDSGTSADVSNVSSFGSGLVASGGAATQALTWALVNTSQLSYADIFIRTREILRQKGYKQVPQLSSSKPVDLYKPFSLFGPITVNTSLIHYVPQQYLQPWGPPQPYYPPPQPQQPYYPPPQPQQPYYPSSQLPTQYNNLAPTAGIPLMTSSSEVPPGQYPQALSGDQNGGVPPQYPSDQSTYYSSAQYLSGVGKPL |
| Enzyme Length | 442 |
| Uniprot Accession Number | Q2VLK8 |
| Absorption | |
| Active Site | ACT_SITE 146; /evidence=ECO:0000305|PubMed:22402587; ACT_SITE 201; /evidence=ECO:0000305|PubMed:22402587 |
| Activity Regulation | ACTIVITY REGULATION: Activated by Ca(2+). {ECO:0000269|PubMed:22402587}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Cysteine protease that cleaves specifically after arginine or lysine residues (PubMed:22402587). May play a role in apoptosis (PubMed:22402587). {ECO:0000269|PubMed:22402587}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (2); Glycosylation (6); Metal binding (4); Mutagenesis (2); Region (3); Signal peptide (1) |
| Keywords | Calcium;Endosome;Glycoprotein;Hydrolase;Metal-binding;Protease;Reference proteome;Signal;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250|UniProtKB:Q8IEW1}. Note=Localizes to RAB11-positive recycling endosomes. {ECO:0000250|UniProtKB:Q8IEW1}. |
| Modified Residue | |
| Post Translational Modification | PTM: In epimastigotes, the unprocessed enzyme appears to be the main form (PubMed:22402587). Auto-processing is dispensable for catalytic activity towards small oligopeptide substrates (PubMed:22402587). {ECO:0000269|PubMed:22402587}. |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 48,698 |
| Kinetics | |
| Metal Binding | METAL 161; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3; METAL 177; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3; METAL 178; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3; METAL 208; /note=Calcium; /evidence=ECO:0000250|UniProtKB:Q585F3 |
| Rhea ID | |
| Cross Reference Brenda |