| IED ID | IndEnz0002013756 |
| Enzyme Type ID | protease013756 |
| Protein Name |
Plasminogen activator inhibitor 2, macrophage PAI-2 Serpin B2 |
| Gene Name | Serpinb2 Pai2 Planh2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MEELSMANTMFALNLLKQIEKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGITTRNPENFSGCDFAQQIQKENYPSAILQAQAGDKIHSAFSSLSSTINTPQGDYLLESANKLFGEKSARFKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKTQILELPHTGNISMLLLLPDEIEDASTGLELLESEINFANFNKWISKDTLDEDDVVVYIPKFKLAQSYELKSILQSMGMEDAFNKGKANFSGMSERNDLFLSEVFHQASVDVTEEGTVAAGGTGAVMTGRTGHGGPQFVADHPFLFFIMDKITHTILFVGRFSSP |
| Enzyme Length | 415 |
| Uniprot Accession Number | P12388 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (4); Natural variant (4); Sequence conflict (2); Signal peptide (1); Site (1) |
| Keywords | Cytoplasm;Glycoprotein;Plasminogen activation;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | PTM: The signal sequence is not cleaved. |
| Signal Peptide | SIGNAL 1..?; /note=Not cleaved |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10431239; 11154109; 11213252; 11221892; 11863365; 12466851; 14597207; 14645112; 15050365; 15203215; 16517735; 17958744; 18632617; 18681831; 20130210; 20837540; 21267068; 21677750; 22203995; 23460840; 23472114; 23630350; 24043792; 24194600; 24581498; 24644264; 25041188; 25489104; 26083412; 26644517; 27109612; 28346421; 29978354; 30093305; 30388956; 31080015; 31455834; 32209589; 7743917; 8211130; 8697804; 8798151; 8902998; 8959348; 9196003; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,292 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |