| IED ID | IndEnz0002013785 |
| Enzyme Type ID | protease013785 |
| Protein Name |
Protein P2-P3 Cleaved into: Serine protease EC 3.4.21.- ; RNA-directed RNA polymerase EC 2.7.7.48 |
| Gene Name | ORF2/ORF3 |
| Organism | Poinsettia latent virus (isolate Euphorbia pulcherrima/Germany/Siepen/2005) (PnLV) (Poinsettia cryptic virus) |
| Taxonomic Lineage | Viruses Riboviria Orthornavirae Pisuviricota Pisoniviricetes Sobelivirales Solemoviridae Polemovirus Poinsettia latent virus Poinsettia latent virus (isolate Euphorbia pulcherrima/Germany/Siepen/2005) (PnLV) (Poinsettia cryptic virus) |
| Enzyme Sequence | MALLGIKLMTLVFAAWLSCCHSSSALPSSGLSGPCLNHSCLLRNSLNGASQWGTILHSPAVGSNCPPCPMMSIMGCSPPKPLQSNSYGVLCSTIASKAKQDLKLCWKEVQTRSEMYSKRISAALIDSLHQAVGMLLMIIIWIWSSIFLVVYHVLAYMTTYHLSSAVCVGFLIFCTICAFRLISWICGDLLAFNVSGLTPIWVNFSESSCPAGLSLRRYKNEKTVEGYKPFIIPQKSPKKSVIELSFSNGSHLGYATCVRLWDGSICLMTAKHCLVKEALLKGRVAGHSLPVKNFDLFLTCDEIDFSLLRGPKQWEAYLGVKGADLITSNRIGRSPVTFYNLSKDGEWLANSAQITGRHGKLCSVLSNTSPGDSGTPYYSGKNVVGIHKGTSELENYNLMIPIPNIPGLTSPDFKFETTNVRGNLYNDEGFRLSVGEDDKAEHWTDRLMKSITFKTKRWADWAEEESESDDERGKVVPPAKPSNYGEGCPPEHNQYLSDVGDLLTKVIGPEQNEKCVDILMGIMGVDKNEVAPHKEEKAEKGKRSSGFGHGKNRKGTNHPMRRGYNFRNCKKGGGQDESESHREISGRDPGRESNDKSPQGEAEEFERYFSSFYSWKLHNSGEANSGFRPCGKIPKFYRPRKRRVSEWGQNLARKHSSLGEITQGFGWPEAGAEAELRSLRLQAQRWLERSKSSVIPSAIEREIVISRLVESYKICRSEAPLCSSGSDLSWKGFLEDFREAVSSLELDAGIGVPYIGYGYPTHRGWVENPRLLPVLSRLVYARLQRLATLSVDGKTPEELVRDGLVDPVRVFVKGEPHKQSKLDEGRYRLIMSVSLIDQLVARVLFQKQNKLELLLWRSIPSKPGFGLSTVEQVEEFIDHLARVVDVKSDDLLENWRELMVPTDCSGFDWSVSDWMLKDEMEVRNRLTINCNDLTRRLRNSWLYCLSNSDLALSDGSLLAQEVPGVQKSGSYNTSSTNSRIRVMAAYFAGASWAVAIGDDALESIDTTLAVYKSLGFKVEVSEDLEFCSHIFKTRSLAIPVNTSKMLYRLIYGYEPECGNLDVLRNYLCALASVLHELRHDQDLVQNLSKWLIPDGSQKIS |
| Enzyme Length | 1100 |
| Uniprot Accession Number | Q5NDM9 |
| Absorption | |
| Active Site | ACT_SITE 272; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01216; ACT_SITE 304; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01216; ACT_SITE 373; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01216 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539}; |
| DNA Binding | |
| EC Number | 3.4.21.-; 2.7.7.48 |
| Enzyme Function | FUNCTION: Precursor from which the RNA-dependent RNA polymerase (RdRp) is probably released. RNA-dependent RNA polymerase plays an essential role in virus replication (Potential). {ECO:0000305}.; FUNCTION: RNA-dependent RNA polymerase replicates the viral genome. {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (3); Compositional bias (2); Domain (2); Region (2); Signal peptide (1); Site (2); Transmembrane (2) |
| Keywords | Host membrane;Hydrolase;Membrane;Nucleotide-binding;Nucleotidyltransferase;Protease;RNA-directed RNA polymerase;Reference proteome;Ribosomal frameshifting;Serine protease;Signal;Transferase;Transmembrane;Transmembrane helix;Viral RNA replication |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 122,814 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:21248 |
| Cross Reference Brenda |