| IED ID | IndEnz0002013801 |
| Enzyme Type ID | protease013801 |
| Protein Name |
RNA replication protein Includes: RNA-directed RNA polymerase EC 2.7.7.48 ; Helicase EC 3.6.4.13 ; Methyltransferase EC 2.1.1.- |
| Gene Name | |
| Organism | Grapevine fleck virus (isolate Italy/MT48) (GFkV) |
| Taxonomic Lineage | Viruses Riboviria Orthornavirae Kitrinoviricota Alsuviricetes Tymovirales Tymoviridae Maculavirus Grapevine fleck virus Grapevine fleck virus (isolate Italy/MT48) (GFkV) |
| Enzyme Sequence | MVLTLCFHSDRDHHFLSTLPLAEIRRLAPGGFSVFVPEDLLPHLSPSPSCPTPPLPRELTWSAACNPTNFPHLFRHHRPPPPCTRLTPRPPPPTPAPPSASTLPRVFHGGAPPAAFQPAIDFLHNTIQKDTIASSIIAALNPSLTSSLTLYPYALPPRWPSALNQAGIPATSYGHQSHPHPIHKTIETHLLHEHWANRATLPSTVMFMKRSKFDKLRVSNAALVKSASNFLHLLNPILTARDADRYTHLPLPDTLPSTPLYFMHHSLMYFSPSQIAGLFLAAPFLERLYASLVLPAESTIGSHPFFPSLYRYRTTGEHLHYVLEGNPSSSYTQPLTATQWLTTSSITAGDLHLTVTVLESWFSVHSILITRGVRPLELPRDIISLPSPDAVLLPNPSAFDIPLRSRLVPRDVCESLFVYVRAVRTLRTTDPAGFIRTQSNKAEFDWVTAEAWDHLAQFALLTAPVRPNTYFLPLLSPLAVVRHWLFRKQRPIFATLTLLSASTAAAIPIAIARLRTHSVTQLTILGHHFTPPKILARLPVALKRLIPKRLLPHLPSHLRPPPSWSPVFTLTFSELPKARFLTFPISGQTHTLLRQLHVPAILFAPQRPSRPLIFAGLLIGTVPVLYGAYRWFVSRFDPQTVYNRYSDLLHRPTWHLTFEREPLSCFPTPFLPHPSSHPRRARRLPPLPPAPPLPPQPPPPPPPQPSPHPPLFPASIPSPPPRPSSPPPPATSPASTPALTPIPAPKTAPPLTFPSPTLVAEPDAPVTARPSPLPLAPSRPFSELYPGHYADHSGSFFLQQPLVASSVPYPALDCLLVSCSAASGIPKEDLWATLCHIFPPSDLVSDLGLSTNHLTALAFTYQWLVTLRSGELVQRHGLLSAPFAFEITHTPPVPPATVGHFALSAPLTPTSACLTGGAPSPVISGPKASASLPRARFGPRPEAPRPPLTPPGFTPITEPTPATSPFALAALRFRLNRQPLPIRQVHAYSIALPRAKNLVSNLKNGFDGLVSSLPASDRTNLLPLIQALDHTADFPPARPPVGLIHIAGFAGCGKSYPIQQLLATQTFRHFRVVTPTTELRHEWKRALKLEGPSSWRVSTWETALAKRASVLVIDEVYKLPRGYLDLALLADPTVEFVIILGDPLQGSYNPTNPDSSNHRLIPEEDHLRPFIDFYCLWTRRLPRLVADFFGVPTTNPTRGHLAFASLNTTQSPLLVPSDSMARALTAGGHRAITYAASQGSTYPAPVHIFLDRNSNLVTNHVALVALTRSRSGVHFRPRAQDLPRHPQHLFTAFYKYAIDLLAHEADPSKPRPTPVDVTLLFQQQLRGLTILRDPSFSRITGGATHAFLAHAPLFTNLHGLRPTTFPDNLPTAPTYLARSLPYHQTESYPTSALPHRVFPASTTDWSAADDHPRVNPTFVAETRLPLQSELAPTLPSQPEPSPTYHSPATFETVYPGVDGEALARTFLAATDPLELEIFFRNNWSNQFPFINRPDTVACNPLTLVAPTHNQKQDPTLLHASLAKRLRFRDSTAPYTITAKDQALGYILYHSLQRAYCRSPEPVPFDPVLFASCIAENDFAQLTSKTQATIQANAFRSDPDWRHTFVRIFSKTQHKVNENSLFTSWKACQTLALMHDYLILVLGPVKKYQRILDSRDRPAHLYIHAGQTPHQLSEWCQNHLTPSVHLANDYTAFDQSQHGEAVVLEAWKMRRASIPEPFITLHVHVKTNIECQFGPLTCMRITGEPGTYDDNTDYNLAILYTQYLLHRTPVLVSGDDSLVDRVPPMNPSWPALAPLFALKPKPETSPFGLFCGYFVGPAGAVRAPRALFAKLAIALEDGSLPEKIASYVAEFSVGQSLGDSLWSLIPPELVIYQSACFDLICRHASPQLKLALRLGEVPDWGSLLSQLKLRFLTRPLFALLDAHTRVMVRTHKAHLLPSGHALHPSTEPFY |
| Enzyme Length | 1949 |
| Uniprot Accession Number | Q8UZB6 |
| Absorption | |
| Active Site | ACT_SITE 814; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01074; ACT_SITE 900; /note=For protease activity; /evidence=ECO:0000255|PROSITE-ProRule:PRU01074 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539}; |
| DNA Binding | |
| EC Number | 2.7.7.48; 3.6.4.13; 2.1.1.- |
| Enzyme Function | FUNCTION: RNA replication protein replicates the viral genomic RNA. The central part of this protein possibly functions as an ATP-binding helicase and/or methyltransferase (Probable). {ECO:0000305}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 1048..1055; /note=ATP; /evidence=ECO:0000255 |
| Features | Active site (2); Chain (1); Compositional bias (2); Domain (5); Nucleotide binding (1); Region (3) |
| Keywords | ATP-binding;Hydrolase;Methyltransferase;Multifunctional enzyme;Nucleotide-binding;Nucleotidyltransferase;Protease;RNA-directed RNA polymerase;Reference proteome;Thiol protease;Transferase;Viral RNA replication |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 215,590 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:13065; RHEA:21248 |
| Cross Reference Brenda |