| IED ID | IndEnz0002013804 |
| Enzyme Type ID | protease013804 |
| Protein Name |
CAAX prenyl protease 2 EC 3.4.-.- Prenyl protein-specific endoprotease 2 PPSEP 2 Ras and A-factor-converting enzyme RACE |
| Gene Name | RCE1 YMR274C YM8156.16C |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MLQFSTFLVLLYISISYVLPLYATSQPEGSKRDNPRTIKSRMQKLTIMLISNLFLVPFLQSQLSSTTSHISFKDAFLGLGIIPGYYAALPNPWQFSQFVKDLTKCVAMLLTLYCGPVLDFVLYHLLNPKSSILEDFYHEFLNIWSFRNFIFAPITEEIFYTSMLLTTYLNLIPHSQLSYQQLFWQPSLFFGLAHAHHAYEQLQEGSMTTVSILLTTCFQILYTTLFGGLTKFVFVRTGGNLWCCIILHALCNIMGFPGPSRLNLHFTVVDKKAGRISKLVSIWNKCYFALLVLGLISLKDTLQTLVGTPGYRITL |
| Enzyme Length | 315 |
| Uniprot Accession Number | Q03530 |
| Absorption | |
| Active Site | ACT_SITE 156; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:Q6LZY8; ACT_SITE 194; /note=Proton donor/acceptor; /evidence=ECO:0000250|UniProtKB:Q6LZY8 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Proteolytically removes the C-terminal three residues of farnesylated proteins, including the a-factor mating pheromone and RAS. {ECO:0000269|PubMed:10825201, ECO:0000269|PubMed:9065405}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Site (2); Topological domain (9); Transmembrane (8) |
| Keywords | Endoplasmic reticulum;Hydrolase;Membrane;Pheromone response;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9736709}; Multi-pass membrane protein {ECO:0000269|PubMed:9736709}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10085068; 10747800; 10760460; 11343912; 11581258; 11950929; 12913070; 16361710; 16963638; 17942791; 19820121; 20162532; 21496492; 22079863; 22933563; 23972033; 24040173; 27129777; 27525482; 9122679; 9559265; 9700155; |
| Motif | |
| Gene Encoded By | |
| Mass | 35,911 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.99.B1; |