| IED ID |
IndEnz0002013825 |
| Enzyme Type ID |
protease013825 |
| Protein Name |
Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial
|
| Gene Name |
|
| Organism |
Euglena gracilis |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Discoba
Euglenozoa
Euglenida (euglenids)
Spirocuta
Euglenophyceae
Euglenales
Euglenaceae
Euglena
Euglena gracilis
|
| Enzyme Sequence |
MTTPSLSSILRHTRPIFKETLRAARPTLQNALPNGFRIASESKDGDTCTVGVWIDAGSRWETEKNNGVAHFLEHMNFKGTGKRSRQDIEFGMEKMGAHLNAYTSREHTCYYVKCFKKDVPEAVDILADILLNSKRTEQDLDAERQTIVQEKEDVEARIDEVLMDHLHSAAFEGSGLGLSILGPLENIQKSITKGMIDDFVKTHYTGPRMALVGSGAVDHGQLCDLASKYFGALPTGQPKPSGFTRFLGGDKRETNQLNPLTHVAVAFQTPGISHPDAIKIKVLEQLLGSYSRDKGEAAYSCFARAIVMDFYDPKVGQFFRPNKAGHNPIHSLNAFWAPYSDVGLLGFYAIAEPGKSYGHEWENILHYAMRELIRVSRNISEEEFERAKNQLKLQTMLQLDGTTNIADDIGRQVLSFGARVPLASFFEQLDAISREDLIRVGPRVLLRQGPRGGGDWRHGQRARVRRPAGGDLLRGPLSCPLCTPLPRQSVVCMA |
| Enzyme Length |
494 |
| Uniprot Accession Number |
P43264 |
| Absorption |
|
| Active Site |
ACT_SITE 73; /note=Proton acceptor; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096 |
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. {ECO:0000250|UniProtKB:P07256}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Active site (1); Chain (1); Metal binding (3); Sequence caution (1); Transit peptide (1) |
| Keywords |
Electron transport;Hydrolase;Membrane;Metal-binding;Metalloprotease;Mitochondrion;Mitochondrion inner membrane;Protease;Respiratory chain;Transit peptide;Transport;Zinc |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07256}; Peripheral membrane protein {ECO:0000250|UniProtKB:P07256}; Matrix side {ECO:0000250|UniProtKB:P07256}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: The N-terminus is blocked. |
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
54,934 |
| Kinetics |
|
| Metal Binding |
METAL 70; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096; METAL 74; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096; METAL 150; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU10096 |
| Rhea ID |
|
| Cross Reference Brenda |
|