| IED ID |
IndEnz0002013847 |
| Enzyme Type ID |
protease013847 |
| Protein Name |
UV excision repair protein RAD23 homolog A
|
| Gene Name |
RAD23A |
| Organism |
Bos taurus (Bovine) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Laurasiatheria
Artiodactyla
Ruminantia
Pecora
Bovidae
Bovinae
Bos (oxen
cattle)
Bos taurus (Bovine)
|
| Enzyme Sequence |
MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVAGQKLIYAGKILSDDVPIRDYRIDEKNFVVVMVTKAKTSPGTSVPSEASPTATPESSTSFPSAPASGMSHPPPTAREDKSPSEESAPTTSPESVSGSVPSSGSGGREEDAASTLVTGSEYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQVSEQPSTEAGENPLEFLRDQPQFQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELVDISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQNFDDE |
| Enzyme Length |
362 |
| Uniprot Accession Number |
A3KMV2 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity). {ECO:0000250}.; FUNCTION: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, XPC:RAD23A dimer has NER activity. Can stabilize XPC (By similarity). {ECO:0000250}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (3); Cross-link (1); Domain (3); Modified residue (8); Region (2) |
| Keywords |
DNA damage;DNA repair;Isopeptide bond;Nucleus;Phosphoprotein;Proteasome;Reference proteome;Repeat;Ubl conjugation |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. |
| Modified Residue |
MOD_RES 123; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54725; MOD_RES 128; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54725; MOD_RES 133; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54725; MOD_RES 136; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54725; MOD_RES 138; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54726; MOD_RES 205; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54725; MOD_RES 294; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54725; MOD_RES 356; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P54725 |
| Post Translational Modification |
|
| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
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| Mass |
39,589 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
|
| Cross Reference Brenda |
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