| IED ID | IndEnz0002013938 |
| Enzyme Type ID | protease013938 |
| Protein Name |
Renin EC 3.4.23.15 Angiotensinogenase |
| Gene Name | REN |
| Organism | Ovis aries (Sheep) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Caprinae Ovis Ovis aries (Sheep) |
| Enzyme Sequence | MPLWGLLLALWGCSTFSLPADTAAFRRIFLKKMPSVRESLKERGVDMAQLGAEWSQLTKTLSFGNRTSPVVLTNYLDTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSPLYTACEIHSLYDSLESSSYVENGTEFTIYYGSGKVKGFLSQDLVTVGGITVTQTFGEVTELPLRPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILAQRVLTEDVFSVYYSRDSKNSHLLGGEIVLGGSDPQYYQENFHYVSISKPGSWQIRMKGVSVRSTTLLCEEGCMVVVDTGASYISGPTSSLRLLMEALGAKELSIDEYVVNCNQMPTLPDISFHLGGKAYTLTSADYVLQDPYNNISCTLALHGMDIPPPTGPVWVLGATFIRKFYTEFDRRNNRIGFALAR |
| Enzyme Length | 400 |
| Uniprot Accession Number | P52115 |
| Absorption | |
| Active Site | ACT_SITE 98; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 286; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094 |
| Activity Regulation | ACTIVITY REGULATION: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. {ECO:0000250}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.; EC=3.4.23.15; |
| DNA Binding | |
| EC Number | 3.4.23.15 |
| Enzyme Function | FUNCTION: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (2); Domain (1); Glycosylation (3); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Membrane {ECO:0000250}. Note=Associated to membranes via binding to ATP6AP2. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 44,016 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |