| IED ID | IndEnz0002013959 |
| Enzyme Type ID | protease013959 |
| Protein Name |
B-cell scaffold protein with ankyrin repeats Protein AVIEF |
| Gene Name | Bank1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MLPVASGTRGSTQDLFQVGLAPPGNAKDILLLYEEDAEEWALYLREIFMRVVEREAILLYPLHSFSSSHLEMLNFYAYKCKLLIISNSLLKDLTPKKCQFLEKILHSTGNVVTLLCGMESSDPFYQLLSIPRKRWEISTEQDPDGYISVIRQILDQGPEDYLEVSIPTDSRAKYPEDTSGQKGTDVLASLRPSVPRVLVLPGEIPCEKPGEIFILLKDELIGEILEVEFISTNKRLRARPARWNKSVWHMKAADFPAGSVTVNIHCDGIIKATTEIKYCSAAKATESPFRVSDPGKSLCQKSIEELDNVLASIFKREIPYYEFKHLQAETYPQKERTHTTELPTLLHCAAKFGLKNLALHLLQCSGATRAARMKATDGSDLLHIAERHGHEELKEVFEDFLSQNTGRNSKQENDYEEDVISFSTYSPSMPSPASLHELRKTHRRNTDRSEEPERSVEMKEEEAGAEARRSLSEGERESSENQYDDLYVFIPGFDTEGNSEEPLPHCRPPLLPPRPGTAASQLERPHFTSQGKVLEDQMERSQNWNDLNARPETREESSREEKKEEAQEEEEEEENPYAFAETEDNEYDLILASKSVKKRTGNRSFIINRPPAPTPRPTHIPPKEETTPYIAQVFQQKAARRQSDGDKFYSLPKKPDKTRMEGPTFPSTRDYLTTGQEELILLQERVKNGKMSVDEALEKFKHWQMGKSGLEMIQQEKLRQLRDNIIGKRPEDENAYDKLTIVHHPSGNTAHNENMLYNSPFNSKFPARIQVEKEFGFCCKKDH |
| Enzyme Length | 783 |
| Uniprot Accession Number | Q80VH0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2 (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (4); Domain (2); Erroneous initiation (1); Erroneous termination (1); Frameshift (1); Modified residue (1); Region (5); Repeat (2); Sequence conflict (8) |
| Keywords | ANK repeat;B-cell activation;Phosphoprotein;Reference proteome;Repeat |
| Interact With | P42227 |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 649; /note=Phosphotyrosine; /evidence=ECO:0007744|PubMed:21183079 |
| Post Translational Modification | PTM: Phosphorylated on tyrosines upon BCR activation. {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12466851; 15102471; 15722412; 16546095; 21267068; 21677750; 23012479; 24227780; 26522721; 27228057; 29370826; 30016332; 31243359; |
| Motif | |
| Gene Encoded By | |
| Mass | 89,406 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |