| IED ID | IndEnz0002013960 |
| Enzyme Type ID | protease013960 |
| Protein Name |
Alpha-2-antiplasmin Alpha-2-AP Alpha-2-plasmin inhibitor Alpha-2-PI Serpin F2 |
| Gene Name | Serpinf2 Pli |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MALLRGLLVLSLSCLQGPCFTFSPVSAVDLPGQQPVSEQAQQKLPLPALFKLDNQDFGDHATLKRSPGHCKSVPTAEETRRLAQAMMAFTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHMNTGSCLPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSERLFGAKPVKLTGKQEEDLANINQWVKEATEGKIEDFLSELPDSTVLLLLNAIHFHGFWRTKFDPSLTQKDFFHLDERFTVSVDMMHAVSYPLRWFLLEQPEIQVAHFPFKNNMSFVVVMPTYFEWNVSEVLANLTWDTLYHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQELFQGPDLRGISEQNLVVSSVQHQSTMELSEAGVEAAAATSVAMNRMSLSSFTVNRPFLFFIMEDTIGVPLFVGSVRNPNPSALPQLQEQRDSPDNRLIGQNDKADFHGGKTFGPDLKLAPRMEEDYPQFSSPK |
| Enzyme Length | 491 |
| Uniprot Accession Number | Q61247 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (13); Chain (1); Disulfide bond (1); Glycosylation (4); Helix (11); Modified residue (1); Propeptide (1); Region (1); Signal peptide (1); Site (3); Turn (4) |
| Keywords | 3D-structure;Acute phase;Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal;Sulfation |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 484; /note=Sulfotyrosine; /evidence=ECO:0000250 |
| Post Translational Modification | PTM: Proteolytically cleaved at Pro-35 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin. {ECO:0000250|UniProtKB:P08697}. |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000269|PubMed:7523120 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 2R9Y; |
| Mapped Pubmed ID | 10090937; 10318667; 10845862; 10891445; 11154109; 11157667; 12466851; 12893771; 12911586; 12941042; 14672621; 15760453; 16839360; 17203182; 17222401; 17958745; 18063751; 18436805; 18554416; 18723692; 20008146; 21267068; 21677750; 22159717; 23646899; 23770230; 24874880; 25256235; 26324704; 26438794; 26743600; 28028005; 28071719; 28677806; 29618843; 31395599; 32179912; 33059734; 9308761; |
| Motif | |
| Gene Encoded By | |
| Mass | 54,972 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |