| IED ID | IndEnz0002013987 |
| Enzyme Type ID | protease013987 |
| Protein Name |
Lys-63-specific deubiquitinase BRCC36-like EC 3.4.19.- |
| Gene Name | C6.1al Gm5136 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAVRMMQGVQAVYLESDAFLVCLNHALSTEKEEVMGLCIGQLNDHGRSDSRLAYAGAEMCTVAKKMEATRIVHIHSVIILRRSDKTKDRVEISPEQLSAASIEAERLAEQTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQSFVGLIFACFIEDKPTKIGRVLYTCFQSVQASKSSEYERLEIPIHIVPRTTIGTVCLRSAIELPGILCQEEQEAYRRIHGLTHLDSVTKIHNGSVFTKHLCSQMSAVCGPLLQWLEDRLEQNQQRLQELEQEKEDLMEELSSLE |
| Enzyme Length | 291 |
| Uniprot Accession Number | Q7M757 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.19.- |
| Enzyme Function | FUNCTION: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Metal binding (3); Motif (1) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Ubl conjugation pathway;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 122..135; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 33,079 |
| Kinetics | |
| Metal Binding | METAL 122; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 124; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 135; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID | |
| Cross Reference Brenda |