| IED ID | IndEnz0002013994 |
| Enzyme Type ID | protease013994 |
| Protein Name |
Acrosin EC 3.4.21.10 Cleaved into: Acrosin light chain; Acrosin heavy chain |
| Gene Name | Acr |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MVEMLPTVAVLVLAVSVVAKDNTTCDGPCGLRFRQNSQAGTRIVSGQSAQLGAWPWMVSLQIFTSHNSRRYHACGGSLLNSHWVLTAAHCFDNKKKVYDWRLVFGAQEIEYGRNKPVKEPQQERYVQKIVIHEKYNVVTEGNDIALLKITPPVTCGNFIGPCCLPHFKAGPPQIPHTCYVTGWGYIKEKAPRPSPVLMEARVDLIDLDLCNSTQWYNGRVTSTNVCAGYPEGKIDTCQGDSGGPLMCRDNVDSPFVVVGITSWGVGCARAKRPGVYTATWDYLDWIASKIGPNALHLIQPATPHPPTTRHPMVSFHPPSLRPPWYFQHLPSRPLYLRPLRPLLHRPSSTQTSSSLMPLLSPPTPAQPASFTIATQHMRHRTTLSFARRLQRLIEALKMRTYPMKHPSQYSGPRNYHYRFSTFEPLSNKPSEPFLHS |
| Enzyme Length | 436 |
| Uniprot Accession Number | P23578 |
| Absorption | |
| Active Site | ACT_SITE 89; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 143; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 241; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by SERPINA5. {ECO:0000250}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.10; |
| DNA Binding | |
| EC Number | 3.4.21.10 |
| Enzyme Function | FUNCTION: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (3); Disulfide bond (6); Domain (1); Erroneous initiation (3); Glycosylation (2); Propeptide (1); Sequence conflict (39); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 11313341; 11739644; 12398221; 12466851; 12930723; 13129914; 1358803; 15051954; 15665108; 15685642; 16141072; 1701633; 17130239; 18689890; 19520787; 20059948; 20106871; 20484738; 21267068; 21383078; 21487003; 21677750; 22362218; 23426433; 24067652; 26264441; 27649575; 7678343; 7798216; 7989357; 8012111; 8401507; 8845149; 9041140; |
| Motif | |
| Gene Encoded By | |
| Mass | 48,929 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |