| IED ID |
IndEnz0002013997 |
| Enzyme Type ID |
protease013997 |
| Protein Name |
Adenosine receptor A2a
|
| Gene Name |
ADORA2A ADORA2 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS |
| Enzyme Length |
412 |
| Uniprot Accession Number |
P29274 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Beta strand (5); Chain (1); Disulfide bond (4); Erroneous initiation (1); Glycosylation (1); Helix (17); Natural variant (3); Region (4); Topological domain (8); Transmembrane (7); Turn (2) |
| Keywords |
3D-structure;Cell membrane;Disulfide bond;G-protein coupled receptor;Glycoprotein;Membrane;Receptor;Reference proteome;Transducer;Transmembrane;Transmembrane helix;Ubl conjugation |
| Interact With |
P30542; Itself; P29275; O15155; P21554; Q99418; O15354; Q7Z6G3; O43759-2; Q13107; Q5T9L3-1; P31424-1 |
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30543}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30543}. Note=Colocalizes with GAS2L2 at neuronal processes. {ECO:0000250|UniProtKB:P30543}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface. {ECO:0000269|PubMed:16339847}. |
| Signal Peptide |
|
| Structure 3D |
Electron microscopy (2); X-ray crystallography (57) |
| Cross Reference PDB |
2YDO;
2YDV;
3EML;
3PWH;
3QAK;
3REY;
3RFM;
3UZA;
3UZC;
3VG9;
3VGA;
4EIY;
4UG2;
4UHR;
5G53;
5IU4;
5IU7;
5IU8;
5IUA;
5IUB;
5JTB;
5K2A;
5K2B;
5K2C;
5K2D;
5MZJ;
5MZP;
5N2R;
5NLX;
5NM2;
5NM4;
5OLG;
5OLH;
5OLO;
5OLV;
5OLZ;
5OM1;
5OM4;
5UIG;
5UVI;
5VRA;
5WF5;
5WF6;
6AQF;
6GDG;
6GT3;
6JZH;
6LPJ;
6LPK;
6LPL;
6MH8;
6PS7;
6S0L;
6S0Q;
6WQA;
6ZDR;
6ZDV;
7ARO;
7RM5;
|
| Mapped Pubmed ID |
10496952;
11140838;
11248116;
11515749;
11934694;
12036966;
12106601;
12189203;
12237741;
12406340;
12429726;
12634474;
12784121;
12804599;
12825092;
12837758;
12856413;
12860470;
12933819;
1325798;
14525968;
14666117;
14715520;
15257174;
15351206;
15362892;
15461468;
15539641;
15704067;
15719154;
15734651;
15774265;
15987888;
16022683;
16027149;
16118787;
16184606;
16280366;
16339780;
16361356;
16481441;
16805430;
16818375;
16824773;
16917093;
16969271;
17132707;
17257240;
17329997;
17356572;
17474152;
17512749;
17558310;
17591446;
17599669;
17616786;
17872970;
18057956;
18197085;
18218631;
18246094;
18305461;
18331682;
18434504;
18442791;
18486613;
18508500;
18524886;
18539621;
18541693;
18577758;
18629431;
18675812;
18759349;
18772204;
18996102;
19013155;
19019012;
19019667;
19086053;
19156168;
19159073;
19262506;
1928448;
19287996;
19303140;
19386617;
19508402;
19525944;
19538256;
19541651;
19565319;
19591938;
19632986;
19776336;
19794965;
19801629;
19883624;
19902562;
19913121;
19948975;
20021407;
20029460;
20045081;
20085598;
20197060;
20334879;
20354569;
20371613;
20386734;
20392501;
20396431;
20413899;
20468064;
20512606;
20520601;
20628086;
20666933;
20691427;
20799992;
20842321;
20926384;
21040702;
21062422;
21062644;
21088442;
21256133;
21258856;
21281405;
21335481;
21393508;
21480628;
21486776;
21501622;
21542986;
21550361;
21590734;
21593763;
21606452;
21633321;
21638125;
21646447;
21658325;
21739164;
21840298;
21885291;
21950736;
21966389;
22012471;
22033526;
22079667;
22119961;
22146575;
22170367;
22213163;
22217884;
22220592;
22238572;
22240468;
22249219;
22286059;
22333316;
22336631;
22356216;
22367999;
22403020;
22462821;
22585593;
22740769;
22754043;
22792196;
22798613;
22844517;
22923002;
22963436;
23005256;
23071116;
23171222;
23193172;
23241554;
23332182;
23377438;
23385980;
23454349;
23478188;
23489072;
23535492;
23583199;
23590306;
23594931;
23597562;
23657626;
23679925;
23682121;
23684610;
23685887;
23695433;
23749290;
23789814;
23856527;
23922714;
23965991;
24321892;
24359090;
24433848;
24509856;
24517244;
24589267;
24652540;
24892887;
24943643;
25175458;
25203160;
25262373;
25285959;
25384972;
25424900;
25445670;
25473121;
2553705;
25573092;
25622143;
25629231;
25644539;
25720391;
25745823;
25762024;
25770019;
25779930;
25818344;
25819143;
25872644;
25935416;
25936513;
25992797;
26066465;
26100888;
26264576;
26317759;
26355151;
26539478;
26589317;
26710963;
26810542;
26873858;
27038930;
27043281;
27144352;
27216911;
27239843;
27241126;
27262510;
27312113;
27334985;
27399166;
27462812;
27476546;
27510168;
27577981;
27595240;
27650530;
27666664;
27672048;
27679816;
27846189;
28060732;
28102227;
28130124;
28167788;
28179537;
28215251;
28418405;
28441750;
28508075;
28548944;
28606618;
28712806;
28743501;
28875031;
28912485;
28921456;
28941407;
28984574;
29126977;
29229601;
29290469;
29300389;
29311713;
29395784;
29524036;
29552726;
29593213;
29636462;
29726815;
29729889;
3037072;
30511252;
30513523;
30581046;
30633335;
30664812;
30713025;
30940903;
30946941;
31098022;
31275983;
3127824;
31324842;
31340557;
31444994;
31578448;
31599329;
31614517;
31709066;
31798359;
31817803;
31973708;
32182774;
32298258;
32367186;
32424513;
32432317;
32488862;
32542862;
32615857;
32709103;
32878560;
32888283;
33027906;
33156955;
33161070;
33168855;
33209311;
33233484;
33235193;
33238145;
33275249;
33342966;
33416945;
33524770;
33764785;
33801676;
33803075;
34070360;
34269678;
34462357;
34631;
34673000;
34818333;
3801783;
8522976;
8527267;
9491818;
9651336;
9880133;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
44,707 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|