| IED ID | IndEnz0002014002 |
| Enzyme Type ID | protease014002 |
| Protein Name |
ADAM DEC1 EC 3.4.24.- A disintegrin and metalloproteinase domain-like protein decysin-1 ADAM-like protein decysin-1 |
| Gene Name | Adamdec1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MLPGTSRLPTEASMSWVLLSVLWLIIQIQVIDATLTPELKPHEIVRPKKLPISQKRGLENNQTERYGKEEKYAPEVQYQIILNGEEIVFHLKRTKHLLGPDYTETSYSPRGEESTRHSQDVKPCYYEGHIQNARGSLARISTCDGLRGYFTHRDQRYQIKPLQSTDEGEHAVLPYSWKGQDTVHDKDAEKQVVRKRSHLRTSRSLKNPNEDLLQGQKYIGLFLVLDNAYYKLYNGNVTQMRTFLFKVLNLLNMIYKTINIQVSLVGMEIWSDQDKIKVEPNLGATFTHFMRWHYSNLGKRIHNHAQLLSGASFRHGRVGMAAGNSFCTTSSVSVIEAKKKNNVALVALMSHELGHALGMKDVPYYTKCPSGSCVMNQYLSSKFPKDFSTVSRSHFQGFLSSRNARCLLLAPDPKNIIKPTCGNQVLDVGEECDCGSPEECTNLCCEPLTCRLKSQPDCSEASNHITE |
| Enzyme Length | 467 |
| Uniprot Accession Number | Q9R0X2 |
| Absorption | |
| Active Site | ACT_SITE 352; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: May play an important role in the control of the immune response and during pregnancy. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Disulfide bond (2); Domain (2); Glycosylation (2); Metal binding (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Zinc;Zymogen |
| Interact With | |
| Induction | INDUCTION: Induced by immunization in mature dendritic cells (DC), in marginal zone (MZ) metallophils, in follicular DC (FDC) and tingible body macrophages of germinal center. Down-regulated by steroid hormones and PRL. {ECO:0000269|PubMed:12606478}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..33; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12037602; 12466851; 16141072; 17268172; 18477666; 21267068; 21677750; 23892084; 27226416; 27480124; |
| Motif | |
| Gene Encoded By | |
| Mass | 52,956 |
| Kinetics | |
| Metal Binding | METAL 351; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 355; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 361; /note=Zinc; catalytic; /evidence=ECO:0000255 |
| Rhea ID | |
| Cross Reference Brenda |