| IED ID | IndEnz0002014040 |
| Enzyme Type ID | protease014040 |
| Protein Name |
Cathepsin B-like CP1 EC 3.4.22.- Cathepsin B-like protease B1 |
| Gene Name | CP1 |
| Organism | Giardia intestinalis (Giardia lamblia) |
| Taxonomic Lineage | cellular organisms Eukaryota Metamonada Fornicata Diplomonadida Hexamitidae Giardiinae Giardia Giardia intestinalis (Giardia lamblia) |
| Enzyme Sequence | MALSLLLAVVCAKPLVSRAELRRIQALNPPWKAGMPKRFENVTEDEFRSMLIRPDRLRARSGSLPPISITEVQELVDPIPPQFDFRDEYPQCVKPALDQGSCGSCWAFSAIGVFGDRRCAMGIDKEAVSYSQQHLISCSLENFGCDGGDFQPTWSFLTFTGATTAECVKYVDYGHTVASPCPAVCDDGSPIQLYKAHGYGQVSKSVPAIMGMLVAGGPLQTMIVVYADLSYYESGVYKHTYGTINLGFHALEIVGYGTTDDGTDYWIIKNSWGPDWGENGYFRIVRGVNECRIEDEIYAVYLD |
| Enzyme Length | 303 |
| Uniprot Accession Number | P92131 |
| Absorption | |
| Active Site | ACT_SITE 105; /evidence=ECO:0000250; ACT_SITE 249; /evidence=ECO:0000250; ACT_SITE 270; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host. {ECO:0000269|PubMed:9150143}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Erroneous initiation (1); Glycosylation (1); Propeptide (1); Sequence conflict (2); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Protease;Signal;Thiol protease;Vacuole;Zymogen |
| Interact With | |
| Induction | INDUCTION: Not expressed without supplemental iron. {ECO:0000269|PubMed:9150143}. |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole {ECO:0000269|PubMed:9150143}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 33,508 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |