| IED ID | IndEnz0002014108 |
| Enzyme Type ID | protease014108 |
| Protein Name |
Disintegrin and metalloproteinase domain-containing protein 5 Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II tMDC II |
| Gene Name | ADAM5 TMDC2 |
| Organism | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
| Enzyme Sequence | MFLLLVLLTGLGGMHADLNPHKTFLQTTIPEKISSSDAKTDPEHNVVYMITIEGKPYFVHLKKQSILSSASFIHSYDKNDIRHSKPLLVQMDCNYNGYVAGIPNSLVTLSVCSGLRGTMQLKNISYGIEPMEAVSGFIHKIYEEKFADTNILLEENDTYSWFNSEYQVRKSSEKTDFIKLFPRYIEMHIVVDKNLFDYMGSDINAVTQKVIQIIGLVNTMLTQLQLTVIISSIEIWSNKNKISTTGHAEYVLLEFFEWKKDHLNFKPHQIAYLFVYRKLPTLIGATFPGQVCNKDFAAAVALYPEGLSLESYTVIIVQLLGLNLGLTYDKTDTCHCSGDVCTMTPKAVYSGGVKDFSVCSLDDFKYISSHNGLTCLQTNPLEMPTYTQRRICGNGLLEGGEECDCGNKDNCTHKLCCDALTCRLKDNAQCGSGDCCSKDCKFKPANTICRKSVDVECDFTEFCNGSYPYCLLDTYVRDGEYCDSGGAFCFQGRCRTFDKQCDDLIGRGSRGAPIFCYDEINTRGDKFGNCGTEYCLFQHILCGKLVCTWEHKDLISRPNLSVIYAHVRDQTCVSTYLPSRKPPPVASTVSKTSYYSVDDRDETFVQDGSVCGPDMYCFKMRCKHVRFLMDFETCEASIECSGHGICNNFNHCHCEKGYNPPHCKPKKEAFGSTDDGHLVPAEKSYMEEGRHAPFQKQRFQLIFYISLPVLIITTAILIKRKKLRELCYRGETESESSVSQESSSNSKSSLSESTSL |
| Enzyme Length | 756 |
| Uniprot Accession Number | Q28483 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Disulfide bond (7); Domain (3); Glycosylation (1); Propeptide (1); Region (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Disulfide bond;EGF-like domain;Glycoprotein;Membrane;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | PTM: Subject to proteolytic processing during epididymal transit of spermatozoa. {ECO:0000269|PubMed:9665629}. |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 85,043 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |