| IED ID | IndEnz0002014183 |
| Enzyme Type ID | protease014183 |
| Protein Name |
Xaa-Pro aminopeptidase EC 3.4.11.9 Aminoacylproline aminopeptidase Aminopeptidase P II APP-II X-Pro aminopeptidase |
| Gene Name | pepP b2908 JW2876 |
| Organism | Escherichia coli (strain K12) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli (strain K12) |
| Enzyme Sequence | MSEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSEYPYRQNSDFWYFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPEKLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADVIVNSALEKLRKGSRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGIGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ |
| Enzyme Length | 441 |
| Uniprot Accession Number | P15034 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; |
| DNA Binding | |
| EC Number | 3.4.11.9 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (19); Chain (1); Helix (18); Initiator methionine (1); Metal binding (7); Turn (1) |
| Keywords | 3D-structure;Aminopeptidase;Cytoplasm;Direct protein sequencing;Hydrolase;Manganese;Metal-binding;Metalloprotease;Protease;Reference proteome |
| Interact With | P60560; P15288 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (26) |
| Cross Reference PDB | 1A16; 1JAW; 1M35; 1N51; 1W2M; 1W7V; 1WBQ; 1WL6; 1WL9; 1WLR; 2BH3; 2BHA; 2BHB; 2BHC; 2BHD; 2BN7; 2BWS; 2BWT; 2BWU; 2BWV; 2BWW; 2BWX; 2BWY; 2V3X; 2V3Y; 2V3Z; |
| Mapped Pubmed ID | 12777807; 15388923; 15690043; 16229471; 16411772; 16606699; 16858726; 17983589; |
| Motif | |
| Gene Encoded By | |
| Mass | 49,815 |
| Kinetics | |
| Metal Binding | METAL 261; /note=Manganese 2; METAL 272; /note=Manganese 1; METAL 272; /note=Manganese 2; METAL 355; /note=Manganese 1; METAL 384; /note=Manganese 1; METAL 407; /note=Manganese 1; METAL 407; /note=Manganese 2 |
| Rhea ID | |
| Cross Reference Brenda | 3.1.8.1;3.4.11.9; |