| IED ID | IndEnz0002014232 |
| Enzyme Type ID | protease014232 |
| Protein Name |
Beta-barrel assembly-enhancing protease EC 3.4.-.- |
| Gene Name | bepA YPO3069 y1412 YP_2691 |
| Organism | Yersinia pestis |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Yersiniaceae Yersinia Yersinia pseudotuberculosis complex Yersinia pestis |
| Enzyme Sequence | MIATLLSSLLLTGPISAGAETQGLLPAQDLLPDIGTSAGATLSIDQEMAMGDFYVRQMRASAPLIYDPLLTQYINTLGNRLVANANSVRTPFHFYLVNNDQINAFAFFGGNVVLHSALFRYTDNESELASVLAHEISHVTQRHLARAMEEQQRLAPLTWVGVLGSILLTMASPQAGMAGLSGTLAGAQQGIISFTQGNEQEADRIGIQVLQRSGFDPQAMPNFLQKLADQSRYVSKPPEMLLTHPLPDSRLSDARNRANQMKPHPTASSQDYLFAKMRILGMYGADENSLTPELLDKLSKGTVREQLAAKYGQAVQLYQAKKYDEARNLLQPLLAQQPGNIWFLDLMTDIDLGQNKSAAAIARLQNAMVKQNDEPVLQLNLANAYVQGRQPAAAIKLLHRYTFAYPNDPNGWDLLAQATATQGLRDQELAARAESLALSGKLTQAIGLLSDASARVKLGSLEQARYDARIDQLRRLNERFRKYQKS |
| Enzyme Length | 486 |
| Uniprot Accession Number | Q8ZCC3 |
| Absorption | |
| Active Site | ACT_SITE 135; /evidence=ECO:0000255|HAMAP-Rule:MF_00997; ACT_SITE 203; /note=Proton donor; /evidence=ECO:0000255|HAMAP-Rule:MF_00997 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. {ECO:0000255|HAMAP-Rule:MF_00997}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous initiation (2); Metal binding (3); Signal peptide (1) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Periplasm;Protease;Reference proteome;Signal;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00997}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255|HAMAP-Rule:MF_00997 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20711500; |
| Motif | |
| Gene Encoded By | |
| Mass | 53,418 |
| Kinetics | |
| Metal Binding | METAL 134; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00997; METAL 138; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00997; METAL 199; /note=Zinc; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_00997 |
| Rhea ID | |
| Cross Reference Brenda |