| IED ID | IndEnz0002014236 |
| Enzyme Type ID | protease014236 |
| Protein Name |
B2 bradykinin receptor B2R BK-2 receptor |
| Gene Name | BDKRB2 BKR2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ |
| Enzyme Length | 391 |
| Uniprot Accession Number | P30411 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Disulfide bond (1); Glycosylation (3); Lipidation (1); Modified residue (6); Natural variant (2); Topological domain (8); Transmembrane (7) |
| Keywords | 3D-structure;Alternative splicing;Cell membrane;Direct protein sequencing;Disulfide bond;G-protein coupled receptor;Glycoprotein;Lipoprotein;Membrane;Palmitate;Phosphoprotein;Receptor;Reference proteome;Transducer;Transmembrane;Transmembrane helix |
| Interact With | P01042 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. |
| Modified Residue | MOD_RES 156; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 347; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 366; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 369; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P25023; MOD_RES 373; /note=Phosphoserine; by GRK6; /evidence=ECO:0000269|PubMed:11517230; MOD_RES 375; /note=Phosphoserine; by GRK6; /evidence=ECO:0000269|PubMed:11517230 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | Electron microscopy (1) |
| Cross Reference PDB | 7F2O; |
| Mapped Pubmed ID | 10191087; 10553917; 11324803; 11409654; 11446495; 11517947; 11699055; 11710536; 11747451; 11908480; 11954665; 12025967; 12039525; 12063092; 12107246; 12130679; 12450400; 12481150; 12489797; 12522467; 12640257; 12705334; 12851878; 14499231; 14607851; 15033977; 15112434; 15114524; 15117835; 15161928; 15301669; 15634338; 15643125; 15643126; 15654972; 15664665; 15771553; 15805101; 15894833; 16144969; 16226010; 16263113; 16294326; 16461337; 16489763; 16600946; 16740128; 16754659; 16950802; 17030791; 17077303; 17110500; 17207964; 17299793; 17303584; 17328065; 17363739; 17420253; 17522594; 17569300; 17593394; 17852785; 18039523; 18096516; 18127230; 18180402; 18187413; 18258629; 18430865; 18467203; 18577758; 18577888; 18810490; 18927465; 18938142; 19017652; 19038786; 1905813; 19074839; 19086053; 19110485; 19120546; 19339996; 19404481; 19420105; 19456859; 19565561; 19578796; 19580784; 19628666; 19716087; 19725054; 19744011; 19854233; 19885862; 19913121; 20036225; 20044476; 20045189; 20050188; 20189583; 20201926; 20300066; 20511677; 20592051; 20602751; 20628086; 20856803; 20944660; 20952631; 21052031; 21108627; 21145390; 21210858; 21451024; 21586566; 21600887; 21602894; 21626144; 21719759; 21871009; 21986469; 22016392; 22047990; 22108573; 22304584; 22468762; 22653778; 22706620; 22900090; 22935637; 23093849; 23127247; 23132855; 23176367; 23224295; 23243416; 23275384; 23351078; 23362199; 23428345; 23454239; 23588115; 23597562; 23613132; 23730990; 23805043; 23826374; 24047499; 24211782; 24236827; 24304135; 24401952; 25109623; 25289859; 2534964; 25529519; 25641172; 25713410; 25842860; 25970620; 26235941; 26360782; 26362411; 26588817; 26764266; 26907838; 26955769; 26982743; 27007662; 2748346; 27696692; 28069442; 28077802; 28099911; 2834384; 29034546; 29334504; 29894755; 30206938; 30236981; 30478260; 30817230; 3086311; 31059006; 31360266; 31552837; 32114020; 32361393; 33412234; 33497625; 3366244; 33686021; 34384552; 34518695; 8015379; 8063797; 8664309; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,461 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |