| IED ID | IndEnz0002014252 |
| Enzyme Type ID | protease014252 |
| Protein Name |
Cercarial protease EC 3.4.21.- Cercarial elastase |
| Gene Name | |
| Organism | Schistosoma mansoni (Blood fluke) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Platyhelminthes Trematoda Digenea (flukes) Strigeidida Schistosomatoidea Schistosomatidae (blood flukes) Schistosoma Schistosoma mansoni (Blood fluke) |
| Enzyme Sequence | MSNRWRFVVVVTLFTYCLTFERVSTWLIRSGEPVQHPAEFPFIAFLTTERTMCTGSLVSTRAVLTAGHCVCSPLPVIRVSFLTLRNGDQQGIHHQPSGVKVAPGYMPSCMSARQRRPIAQTLSGFDIAIVMLAQMVNLQSGIRVISLPQPSDIPPPGTGVFIVGYGRDDNDRDPSRKNGGILKKGRATIMECRHATNGNPICVKAGQNFGQLPAPGDSGGPLLPSLQGPVLGVVSHGVTLPNLPDIIVEYASVARMLDFVRSNI |
| Enzyme Length | 264 |
| Uniprot Accession Number | P12546 |
| Absorption | |
| Active Site | ACT_SITE 68; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 126; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 218; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Activated by an autocatalytic mechanism. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: This protease cleaves elastin and thus facilitates penetration of schistosome parasite larvae through elastin-rich tissue of the host. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (2); Domain (1); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Hydrolase;Protease;Reference proteome;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 28,545 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |