IED Industry Enzyme Database

Detail Information for IndEnz0002014269
IED ID IndEnz0002014269
Enzyme Type ID protease014269
Protein Name T-cell-specific surface glycoprotein CD28
CD antigen CD28
Gene Name Cd28
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MTLRLLFLALNFFSVQVTENKILVKQSPLLVVDSNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRSNAEFNCDGDFDNETVTFRLWNLHVNHTDIYFCKIEFMYPPPYLDNERSNGTIIHIKEKHLCHTQSSPKLFWALVVVAGVLFCYGLLVTVALCVIWTNSRRNRLLQSDYMNMTPRRPGLTRKPYQPYAPARDFAAYRP
Enzyme Length 218
Uniprot Accession Number P31041
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. {ECO:0000250|UniProtKB:P10747}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Beta strand (1); Chain (1); Disulfide bond (2); Domain (1); Glycosylation (4); Modified residue (3); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (1)
Keywords 3D-structure;Disulfide bond;Glycoprotein;Immunoglobulin domain;Membrane;Phosphoprotein;Reference proteome;Signal;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Modified Residue MOD_RES 187; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P10747; MOD_RES 189; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P10747; MOD_RES 207; /note=Phosphotyrosine; /evidence=ECO:0000250|UniProtKB:P10747
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000250
Structure 3D NMR spectroscopy (1)
Cross Reference PDB 2NAE;
Mapped Pubmed ID 10078224; 10201986; 10229827; 10415007; 10429671; 10477557; 10477582; 10477604; 10477605; 10502560; 10510372; 10528184; 10586076; 10605004; 10605050; 10679081; 10693874; 10725709; 10725714; 10725727; 10742150; 10748232; 10779746; 10791997; 10795741; 10878386; 10880049; 10880526; 10899917; 10953030; 11016460; 11046015; 11052947; 11086053; 11092808; 11120807; 11120867; 11145712; 11157849; 11160311; 11238558; 11238622; 11247636; 11276203; 11285307; 11329056; 11342617; 11342622; 11350825; 11489978; 11509650; 11526404; 11544297; 11567634; 11696572; 11698427; 11698433; 11698438; 11698463; 11707574; 11723074; 11801669; 11826754; 11837936; 11861872; 11884443; 11908941; 11929778; 11937529; 11937538; 11937552; 11958588; 11970987; 12044964; 12047751; 12055251; 12070288; 12077322; 12096029; 12097399; 12142553; 12147624; 12193687; 12193694; 12218136; 12239309; 12391201; 12432568; 12444136; 12466851; 12471093; 12496383; 12515810; 12525576; 12538664; 12538715; 12574364; 12574376; 12591901; 12626553; 12663542; 12672399; 12707299; 12752681; 12759417; 1281186; 12829795; 12835481; 12867038; 12874832; 12902500; 12923072; 12925852; 12937416; 12946999; 12960172; 12960297; 1320641; 1347472; 1431091; 14500627; 14500690; 14501867; 14523041; 14581610; 14586728; 14625545; 14634147; 14701943; 14707048; 14707071; 14734751; 14973438; 15004555; 15016653; 15024044; 15034031; 15039422; 15100324; 15128741; 15128767; 15128772; 15135297; 15187121; 15210771; 15210777; 15210826; 15213110; 15240667; 15294937; 15314039; 15356139; 15357951; 15385476; 15467837; 15488732; 15494542; 15514586; 15536066; 15539158; 15585831; 15585834; 15611240; 15629449; 15634900; 15634938; 15640801; 15657954; 15661893; 15661906; 15689402; 15703298; 15728451; 15808517; 15809349; 15814667; 15814687; 15994233; 16081804; 16091384; 16116168; 16141072; 16148116; 16239544; 16239547; 16301632; 16301634; 16311599; 16365402; 16369024; 16424156; 16424201; 16424212; 16462800; 16463658; 16493028; 16493033; 16495554; 16517696; 16546096; 16585571; 16600196; 16635747; 1671668; 16724117; 16751384; 16771859; 16791878; 16809611; 16908623; 16934307; 16940527; 17015685; 17055754; 17056536; 17114448; 17114476; 17119120; 17122127; 17128276; 17202836; 17215523; 17339461; 17371988; 17376197; 17463170; 17494743; 17513738; 17548606; 17617592; 17617602; 17618911; 17629517; 17635872; 17641007; 17690315; 17702861; 17720157; 17873878; 17947665; 17956982; 17982038; 18006698; 18031697; 18056348; 18097000; 18172933; 18178855; 18205792; 18250436; 18259608; 18270248; 18287017; 18310064; 18328742; 18331719; 18354169; 18354182; 18390727; 18523243; 18606642; 18606681; 18628995; 18641318; 18684917; 18780833; 18792405; 18829987; 18832683; 18835195; 18848473; 19017952; 19035513; 19050242; 19050251; 19060239; 19077085; 19109140; 19122654; 19179471; 19188497; 19190244; 19217324; 19234153; 19234186; 19249753; 19268606; 19326996; 19333372; 19398542; 19398586; 19418202; 19454657; 19535626; 19646680; 19672303; 19682930; 19721011; 19770391; 19949106; 19950180; 19966302; 20007249; 20065109; 20137986; 20215643; 20228198; 20421644; 20471291; 20601595; 20601598; 20628601; 20713624; 20870175; 20956339; 21040905; 21183789; 21245484; 21262800; 21267068; 21277900; 21346228; 21357256; 21389258; 21447398; 21490618; 21530327; 21606508; 21690252; 21745657; 21844387; 21931534; 21949024; 21964608; 22068237; 22156342; 22231701; 22285481; 22393155; 22522653; 22585421; 22585681; 22700722; 22732586; 22733595; 22896637; 22908331; 22949644; 23006848; 23047820; 23065717; 23102920; 23144170; 23281398; 23300712; 23348953; 23487421; 23589618; 23671671; 23690575; 23716674; 23793062; 23851689; 23896981; 23908246; 23918985; 23966623; 24042341; 24048955; 24098053; 24270545; 24280042; 24336670; 24487434; 24493803; 24516382; 24633226; 24639356; 24688023; 24711580; 24752446; 24909888; 25029551; 25054224; 25180634; 25318356; 25347065; 25347469; 25355918; 25377239; 25455592; 25533288; 25548162; 25637021; 25680271; 25725801; 25801976; 25825447; 25833397; 26146074; 26249010; 26301814; 26408668; 26485613; 26507712; 26711629; 26773151; 27122236; 27180986; 27183621; 27396441; 27432861; 27460989; 27521344; 27647348; 28053234; 28248972; 28550204; 28783663; 28798231; 28919076; 29042364; 29058713; 29093061; 29425339; 29661826; 29773802; 29862277; 30007439; 30148845; 30320878; 31010850; 31565151; 31636135; 31885821; 32406182; 32414925; 32457739; 32579940; 32765524; 33158954; 33168576; 33169838; 33293517; 34145060; 34157302; 34214472; 34236047; 34281386; 7515723; 7525726; 7534617; 7539104; 7544393; 7545666; 7642234; 7688139; 7751626; 7790813; 7822814; 7882171; 7989745; 8125140; 8384947; 8610339; 8648099; 8649453; 8676068; 8676089; 8683128; 8717514; 8752911; 8808683; 8898959; 8934574; 8943384; 8992981; 9075933; 9126966; 9144484; 9199871; 9208839; 9294148; 9295036; 9317105; 9368605; 9379007; 9414285; 9436464; 9498765; 9529332; 9541582; 9647206; 9653096; 9653097; 9732701; 9759851; 9886387; 9973382;
Motif
Gene Encoded By
Mass 25,243
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda