| IED ID | IndEnz0002014452 |
| Enzyme Type ID | protease014452 |
| Protein Name |
Autophagy-related protein 21 Cytoplasm to vacuole transport protein 21 Homologous with SVP1 protein 1 Maturation of proaminopeptidase I protein 1 |
| Gene Name | ATG21 CVT21 HSV1 MAI1 YPL100W |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKKTSNNNGSASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEMLFSTSLIAIADRGQGLNKGKKLKIVNTKRKCTICEIVFPHEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLANATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNGHWNEEEYILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNESNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT |
| Enzyme Length | 496 |
| Uniprot Accession Number | Q02887 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage. Essential for maturation of proaminopeptidase I. {ECO:0000269|PubMed:11536337, ECO:0000269|PubMed:11852075, ECO:0000269|PubMed:15155809, ECO:0000269|PubMed:15194695, ECO:0000269|PubMed:16876790, ECO:0000269|PubMed:18769150, ECO:0000269|PubMed:19793921, ECO:0000269|PubMed:20154084, ECO:0000269|PubMed:22108003}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Modified residue (2); Motif (1); Mutagenesis (1); Region (1); Repeat (3) |
| Keywords | Autophagy;Cytoplasm;Phosphoprotein;Protein transport;Reference proteome;Repeat;Transport;Vacuole;WD repeat |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Vacuole. Note=And perivacuolar punctate structures. |
| Modified Residue | MOD_RES 213; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:19779198; MOD_RES 237; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:17287358 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11169858; 15350980; 15615779; 16247502; 16860663; 17005271; 17224625; 17890363; 18006683; 18701704; 18719252; 18725539; 19272020; 19536198; 19619494; 19653858; 19802558; 19841731; 20124347; 20146925; 20223289; 20487284; 20712412; 20811355; 21121900; 21194379; 21315770; 21317551; 21327066; 21404646; 21490802; 21548784; 22374087; 22536249; 22550491; 22753491; 22768199; 22992453; 23069643; 23416930; 23669359; 23750326; 24366339; 24366340; 24710476; 24789822; 25070953; 25568150; 25691244; 25747593; 26108642; 26908221; 27381245; 27693354; 30670610; |
| Motif | MOTIF 342..346; /note=L/FRRG motif; /evidence=ECO:0000269|PubMed:15155809 |
| Gene Encoded By | |
| Mass | 55,188 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |