| IED ID | IndEnz0002014459 |
| Enzyme Type ID | protease014459 |
| Protein Name |
Alpha-1-antiproteinase Alpha-1-antitrypsin Alpha-1-proteinase inhibitor |
| Gene Name | |
| Organism | Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Metatheria Didelphimorphia Didelphidae (opossums) Didelphinae Didelphis Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) |
| Enzyme Sequence | MMPSTLSLCLMLAGLCSLVTSHLTEEIQASNDTENEYSSTRRISPYMTDFSIDFYRLLVSKSNTTNIFFSPISIYTAFTLLALGAKSATRDQILTGLRFNRTEISEEHIFEGFQQLLNTFNLPENELQLTTSNGLFIDKNLKLVAKFLEDSKRLYASDTFSTNFEDNMAAKKQINDYVEKETQGKIVDLIQNLDSNVVFVLVNCIFFKGKWEKPFMTELTTECPFHVDSKTTVPVQTMRRLGMFNVFYDQDLSCWVLKMKYMGNATALFILPDTGKIEKVENALNKMLFHKWTRNLKRRAISLYFPKVSISGNYDLKILRELGITDVFGSNADLSGITEETNLKLSQAVHKAVVNIDEKGTEASGATFAEGIPMSIPPTVEFLRPFIFIILEENTKSVLFMGKVMNPTGN |
| Enzyme Length | 410 |
| Uniprot Accession Number | Q03044 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (3); Modified residue (1); Region (1); Signal peptide (1); Site (1) |
| Keywords | Acute phase;Direct protein sequencing;Glycoprotein;Phosphoprotein;Protease inhibitor;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 375; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01009 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000269|PubMed:8422360 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 46,441 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |