| IED ID | IndEnz0002014461 |
| Enzyme Type ID | protease014461 |
| Protein Name |
Alpha-1-antitrypsin Alpha-1 protease inhibitor Alpha-1-antiproteinase |
| Gene Name | |
| Organism | Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Gerbillinae (gerbils) Meriones (jirds) Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) |
| Enzyme Sequence | MTSSISWGLLLLAGLCCLVPSFLAEDAEKTDSSHQDHIMASNLADFAFGLYRVLSHQSNTTNIFLSPLSIATALAMLSLGSKDDTKAQLLQGLHFNLTETSEADIHKGFQHLLKTLNRPDNELQLTTGSSLFVNNSLNLVEKFLEEVKNHYHSEAFFVNFADSEEAKKTINSFVEKATHGKIVDLVKDLEIDTVLALVNYIFFRGKWEKPFDPELTEEADFHVDKSTTVKVPMMNRMGMFDVHYCDTLSSWVLLMDYLGNATAIFILPDEGKMQHLEQTLTKEHIYKFLQNRHTRSANVHLPKLSISGTYNLKKVLSPLGITQVFSNGADLSGITTDVPLKLSKAVHKAVLTLDERGTEAAGTTVLEAVPMSIPPDVCFKNPFVVIICDKHTQSPLFVGKVVNPTQ |
| Enzyme Length | 406 |
| Uniprot Accession Number | Q64118 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibitor of serine proteases. Can inhibit elastase, trypsin, chymotrypsin and plasmin. {ECO:0000269|PubMed:7852275}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (3); Modified residue (2); Region (1); Signal peptide (1); Site (1) |
| Keywords | Direct protein sequencing;Glycoprotein;Phosphoprotein;Protease inhibitor;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | MOD_RES 33; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01009; MOD_RES 372; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P01009 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,127 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |