| IED ID |
IndEnz0002014469 |
| Enzyme Type ID |
protease014469 |
| Protein Name |
Biofilm-associated metzincin protease inhibitor
|
| Gene Name |
bamI PA2782 |
| Organism |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Pseudomonadales
Pseudomonadaceae
Pseudomonas
Pseudomonas aeruginosa group
Pseudomonas aeruginosa
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
|
| Enzyme Sequence |
MAKTWIYAASAAAIGGALIGGWLLDPAPPEASPQARQSPAAQAAAAPTAALAAPAADATRMLAPTPVTTPAPRERVTLWQGELRSREGAQGIPEYLAQVEPALLDTLALGQVLEMSLPGRERPLQARLASTHNSAGLPVWRGGLVDGDEAESLTVVRGSLETHINVATLDGSYSIIVDNRSGKTRVIDENDIAARSDPHGDHVDAPLAELPPMPPPAQG |
| Enzyme Length |
219 |
| Uniprot Accession Number |
Q9I061 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Inhibitor of the metalloendopeptidase Mep72. Forms a protein-protein complex with the protease, which is the product of its coregulated adjacent gene, and probably prevents premature protease activity until the protein has been secreted. {ECO:0000269|PubMed:25488299}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Region (1); Transmembrane (1) |
| Keywords |
Cell membrane;Membrane;Metalloenzyme inhibitor;Metalloprotease inhibitor;Protease inhibitor;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With |
|
| Induction |
INDUCTION: Constitutes an operon together with PA2783. Its expression is up-regulated in biofilms, while it is poorly expressed in planktonic cells. {ECO:0000269|PubMed:25488299}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
22,728 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|