Detail Information for IndEnz0002014471
IED ID IndEnz0002014471
Enzyme Type ID protease014471
Protein Name B-cell scaffold protein with ankyrin repeats
Gene Name BANK1
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MLPAAPGKGLGSPDPAPCGPAPPGNTKDIIMIYEEDAEEWALYLTEVFLHVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLTPKKCQFLEKILHSPKSVVTLLCGVKSSDQLYELLNISQSRWEISTEQEPEDYISVIQSIIFKDSEDYFEVNIPTDLRAKHSGEISERKEIEELSEASRNTIPLAVVLPTEIPCENPGEIFIILRDEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEFPAGSVHVNVYCDGIVKATTKIKYYPTAKAKECLFRMADSGESLCQNSIEELDGVLTSIFKHEIPYYEFQSLQTEICSQNKYTHFKELPTLLHCAAKFGLKNLAIHLLQCSGATWASKMKNMEGSDPAHIAERHGHKELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPSTQNPAFHHESRKTYGQSADGAEANEMEGEGKQNGSGMETKHSPLEVGSESSEDQYDDLYVFIPGADPENNSQEPLMSSRPPLPPPRPVANAFQLERPHFTLPGTMVEGQMERSQNWGHPGVRQETGDEPKGEKEKKEEEKEQEEEEDPYTFAEIDDSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPKEETTPYIAQVFQQKTARRQSDDDKFCGLPKKQDRARIESPAFSTLRGCLTDGQEELILLQEKVKNGKMSMDEALEKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKLTIVHHPGGKETAHNENKFYNVHFSNKLPARPQVEKEFGFCCKKDH
Enzyme Length 785
Uniprot Accession Number Q8NDB2
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (4); Chain (1); Compositional bias (1); Domain (2); Frameshift (1); Natural variant (3); Region (5); Repeat (2); Sequence conflict (5)
Keywords ANK repeat;Alternative splicing;B-cell activation;Phosphoprotein;Reference proteome;Repeat;Systemic lupus erythematosus
Interact With P51451; P07948
Induction
Subcellular Location
Modified Residue
Post Translational Modification PTM: Phosphorylated on tyrosines upon BCR activation. {ECO:0000269|PubMed:11782428}.
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 19110536; 19180476; 19339986; 19357697; 19644876; 19815934; 19877059; 20131273; 20379614; 20472928; 20618440; 20711500; 20848568; 20881011; 20962850; 21068098; 21078628; 21208380; 21900951; 21978998; 21989138; 22003931; 23065315; 23555801; 23899688; 24085759; 24127308; 24342660; 24879116; 24955142; 25608828; 26420661; 26821283; 27313329; 27671502; 27816669; 28466820; 28925718; 30096841; 30145638; 31101814; 31134304; 33756160; 33815360; 34066164; 34127828;
Motif
Gene Encoded By
Mass 89,282
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda