| IED ID |
IndEnz0002014471 |
| Enzyme Type ID |
protease014471 |
| Protein Name |
B-cell scaffold protein with ankyrin repeats
|
| Gene Name |
BANK1 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MLPAAPGKGLGSPDPAPCGPAPPGNTKDIIMIYEEDAEEWALYLTEVFLHVVKREAILLYRLENFSFRHLELLNLTSYKCKLLILSNSLLRDLTPKKCQFLEKILHSPKSVVTLLCGVKSSDQLYELLNISQSRWEISTEQEPEDYISVIQSIIFKDSEDYFEVNIPTDLRAKHSGEISERKEIEELSEASRNTIPLAVVLPTEIPCENPGEIFIILRDEVIGDTVEVEFTSSNKRIRTRPALWNKKVWCMKALEFPAGSVHVNVYCDGIVKATTKIKYYPTAKAKECLFRMADSGESLCQNSIEELDGVLTSIFKHEIPYYEFQSLQTEICSQNKYTHFKELPTLLHCAAKFGLKNLAIHLLQCSGATWASKMKNMEGSDPAHIAERHGHKELKKIFEDFSIQEIDINNEQENDYEEDIASFSTYIPSTQNPAFHHESRKTYGQSADGAEANEMEGEGKQNGSGMETKHSPLEVGSESSEDQYDDLYVFIPGADPENNSQEPLMSSRPPLPPPRPVANAFQLERPHFTLPGTMVEGQMERSQNWGHPGVRQETGDEPKGEKEKKEEEKEQEEEEDPYTFAEIDDSEYDMILANLSIKKKTGSRSFIINRPPAPTPRPTSIPPKEETTPYIAQVFQQKTARRQSDDDKFCGLPKKQDRARIESPAFSTLRGCLTDGQEELILLQEKVKNGKMSMDEALEKFKHWQMGKSGLEMIQQEKLRQLRDCIIGKRPEEENVYNKLTIVHHPGGKETAHNENKFYNVHFSNKLPARPQVEKEFGFCCKKDH |
| Enzyme Length |
785 |
| Uniprot Accession Number |
Q8NDB2 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (4); Chain (1); Compositional bias (1); Domain (2); Frameshift (1); Natural variant (3); Region (5); Repeat (2); Sequence conflict (5) |
| Keywords |
ANK repeat;Alternative splicing;B-cell activation;Phosphoprotein;Reference proteome;Repeat;Systemic lupus erythematosus |
| Interact With |
P51451; P07948 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
PTM: Phosphorylated on tyrosines upon BCR activation. {ECO:0000269|PubMed:11782428}. |
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
19110536;
19180476;
19339986;
19357697;
19644876;
19815934;
19877059;
20131273;
20379614;
20472928;
20618440;
20711500;
20848568;
20881011;
20962850;
21068098;
21078628;
21208380;
21900951;
21978998;
21989138;
22003931;
23065315;
23555801;
23899688;
24085759;
24127308;
24342660;
24879116;
24955142;
25608828;
26420661;
26821283;
27313329;
27671502;
27816669;
28466820;
28925718;
30096841;
30145638;
31101814;
31134304;
33756160;
33815360;
34066164;
34127828;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
89,282 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|