| IED ID | IndEnz0002014472 |
| Enzyme Type ID | protease014472 |
| Protein Name |
Alpha-2-antiplasmin Alpha-2-AP Alpha-2-plasmin inhibitor Alpha-2-PI Serpin F2 |
| Gene Name | SERPINF2 AAP PLI |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK |
| Enzyme Length | 491 |
| Uniprot Accession Number | P08697 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269|PubMed:15853774}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Chain (1); Compositional bias (1); Cross-link (1); Disulfide bond (1); Glycosylation (4); Modified residue (1); Natural variant (8); Propeptide (1); Region (2); Sequence conflict (5); Signal peptide (1); Site (3) |
| Keywords | Acute phase;Alternative splicing;Direct protein sequencing;Disease variant;Disulfide bond;Glycoprotein;Isopeptide bond;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal;Sulfation |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 484; /note=Sulfotyrosine; /evidence=ECO:0000269|PubMed:2434496 |
| Post Translational Modification | PTM: Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin. {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}. |
| Signal Peptide | SIGNAL 1..27; /evidence="ECO:0000269|PubMed:1385210, ECO:0000269|PubMed:8484741" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10090937; 12549929; 12911586; 134998; 16828203; 17203182; 17317851; 17388801; 17883703; 17890952; 17961166; 18048863; 18550704; 19073825; 19492163; 19691486; 19913121; 20071328; 20112045; 20553378; 20628086; 21251197; 21471521; 21486949; 21505192; 21543325; 21707521; 21988832; 23640497; 23992406; 24034420; 24659849; 24818165; 25065555; 25331118; 25464232; 26088309; 26626994; 26743600; 27861608; 28710283; 29306602; 30020241; 31129263; 31282989; 31653347; 32815915; 32945390; 34830419; 6457647; 8467233; |
| Motif | |
| Gene Encoded By | |
| Mass | 54,566 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |