| IED ID |
IndEnz0002014479 |
| Enzyme Type ID |
protease014479 |
| Protein Name |
Alpha-2-macroglobulin
|
| Gene Name |
RC0835 |
| Organism |
Rickettsia conorii (strain ATCC VR-613 / Malish 7) |
| Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Alphaproteobacteria
Rickettsiales
Rickettsiaceae
Rickettsieae
Rickettsia
spotted fever group
Rickettsia conorii
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
|
| Enzyme Sequence |
MKNIFRKFVFTIFVCLINLQLIAASFNEKIPLYFKLTNENLLAGQNALNIDLCDSRIKEWCTKPQRELGLNGKKINDYISISPDIKGEWRFGWWYNINFTPESNFVAHQTYKITIEDYIFPNFVGLKSNNISFTTLPLLPIIKEMNYLQDNIDISKKFVQTKIAFNYPIDPKTLEERIEFIKSSTKEKLPFSIKFNTNNTEATIITNIPPLTDKEDTISVIIKDGVKPLHGGEVFTYKNVKDPNNKTPNNIRYSYKENVLIPSLSSYLKITNSTATIVKDDKLKPEQIIIITTNTPVSGEEIKKHLELFLLPQDKPAFLGVAGKKNYKWQNPKEITDDILKSSEKINFELLSSVPSITTMHSFKVDTFASRALLVKVNQGVKTSDNLTLGSDYFQIVQIPDNPKEVKLMSDGSILSLAGKRKLPVYSLGIDKLYLEIDRINQQEVNHLISQTNRYNIFQNPTFINEYTFNEYNISEVFQEEVIVNSQNLNLPHYTDLDFSKYFNLEEAGSYSKGLFLAKVYAKDNNNIISQDKRLILVTDLGCIVKTDKTGTHHIFVSYISNGKPAGGVKADIIGLNGEVLVSSKTDSKGHAVLSNINDFSKEKTPVAYILTTKDDFAFMPYSRIDRQVNYSRFDVAGAVSSDQGLKAYLFSDRGIYRPNEQGHIGIMLKQTDWQGKFDGLPLEIQVTNPRGKVIDKSKIVLDAEGFGEYLFSTLDDALTGLYNISLYLVGDKGSNNYLNSVSVRVGDFQPDRMKININFNNSQDELWTNPKDLKATVNLINLYGTPAENRKVSGFIDIRPTEFFVPRFKEYKFYSSKGNKEFFYERLGDITTDSKGTANFDLNLEKYYNATFNLTFSAEGFEPDSGRSVNASKSLIVSPLPYIIGFRSDSDLKYIKTKTSAAIEFIAISNKAEKVAAPNLTLNLKKINYVNNLVADSNGNYSYSSVPIETNISSDKINITANESYIYKVPTKEAGDYVIYLTDKEDTIFAQAEFSVIGEGNVTANLTDKANLKVKLDKDDYTAGDTILLNIITPYTGYGLITIETDKVHNFEWFKADENNSIQEIKIPDGFEGKGYVNVQFIRDIEATEIFISPFSYAVVPFTAGIYKHKQDIGLTLPAKIKSGEKLAIRYRTTNPGKIIIFAVDAGILSFAGYQTPDPLNYFINDKALEVRTSQIMDLILPERPLLMKAYMAAPAGDGCINVARNLNPFKRKSQPPIAFWSGILEADLDEREVTFDIPSYFNGTLRVIGVASSLDSIGTSKADLLVQSDLIINPNLPLFVAPNDEFTVPVTIFNNLKDSGNAQVFLNIETSEGLKILDYPKEIPIDENKEATINVKLKATDQLGSADLKVVASINHLKPDIISMAVVHSSELTSTTSVRPASPSVTTVNTGFITDNKANLKILRDVYPEFAKLQISASKSPLAIISGFKDFLDNYPYGCTEQLISQNFANILLYNEQELVQILKTDRKNMDESLSKIFQTLSERQNYDGGFRYWNNFNDDSDPFISVYAMHFLSEGATRYLAVPSDTFNQGIYYLENMANRSINSLDEAREKAYAVYILTQNSVITTSYIANILKYLDEYHKNTWQDDLTSVYLAASYKMLQMNEEAEKLLDRFTLNKPISKTDYQYYNPLIKYSQYLYLIAMHFPERLKDFDPKIVQDIALFAKDNYNSLSASYAIMASLAYADKINHVDEATIKVTSTDKEVTLKGNKVMIAELSVENKNIDLTSSSNGFFYQLLTSGYDKQLTENKEIVKGIEITKKYLDENNKEVSKVKLGDNITVEITMRSGSNKTLSNMVLIDLLPAGFELLPDNNHINILERTQEVMIWKPIYINNRDDRVMIFGTISDQKMTYQYKIKAVNKGIFSTPAIYSEAMYDPQTYYRGVIGNIIVE |
| Enzyme Length |
1892 |
| Uniprot Accession Number |
Q92HD6 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Protects the bacterial cell from host peptidases. {ECO:0000250|UniProtKB:P76578}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Cross-link (1); Signal peptide (1) |
| Keywords |
Protease inhibitor;Signal;Thioester bond |
| Interact With |
|
| Induction |
|
| Subcellular Location |
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| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
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| Gene Encoded By |
|
| Mass |
213,784 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
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| Cross Reference Brenda |
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