| IED ID |
IndEnz0002014488 |
| Enzyme Type ID |
protease014488 |
| Protein Name |
Accessory gland protein Acp36DE
|
| Gene Name |
Acp36DE CG7157 |
| Organism |
Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Acalyptratae
Ephydroidea
Drosophilidae (pomace flies)
Drosophilinae
Drosophilini
Drosophila (fruit flies)
Sophophora
melanogaster group
melanogaster subgroup
Drosophila melanogaster (Fruit fly)
|
| Enzyme Sequence |
MWTLTCQQFIALILLGTLVPSESFLCKHCFRKNLEKVHESFRDILSPPIFGVNPQPLIEVQQPKVTPKPESSQVIHVHQPQVILKPIYYPKVDTISTKNQIGIHGPYSQYPSLLPSANLLGIPNQQLINAQDVLSDKDQKQTQVQNNNLHIRFGVSALREGRNNPSLETISRDKVDKISPALQLQLLRYADSQSQSQTQSQSASQSESNASSQFQAQEQSNRLLENPPVSESQSQSESQSQSESQKQSQSQSQRQQQIQTQLQILRQLQQKSNEQSAAQSASQIQSQRQSDSQSNLQLQEQSQSQSEQGKPIQSQIQILQGLQQKELDDKSASQSQSESKTRQEQQKQLNLQQLEELSSSLSQSRLGLGQQIQSQLQKNQLDKQFASQFQSQSKSQLEQQMQLQLQSLRQLQQKQLDEQSASQSQPQSQVAQQIQSHLQLLRLLQSRLKTQSALKSDLEQQILLQLKKLTEVQQKQLAEQPTLRPSSKSQSPGQLEQQILLQLQNLLQFQQNQLKSDTQTQSQLQESKSNSLSQSQSQSQEQLQLQRDQNLRQLEQIKLEMQNIRELLQKGKSELQTQSDSQRRIHELYQNILQLNKEKLSYQLKQLKLKELEDQKKSQAEISKGSNPSNLFIIGQLPSEGKPAPGNQGPSIEPKLVPQPGSLDKLPSGGGLIGKPASTGLYILSPDFNDLSDYRDQFRLQQELKKHQNILSLLQRRQNDIKKQQNAQLLLGQQQKEQQAQESINKQQSSSAGSSSQTKLQQDIQSTGAQGSQQGLQAGSTGLQTSSLQGTESSASQSAALQRLKEQEQLRIQTENDQKTSSSSSHSNSQNSQSSSSQSSQASQSEAQRQEAGNRNTLLLDQSSSKTQSESKSESSSQSSSHSSSQSTSNSSSNVQSKLQGESQALLNNLSG |
| Enzyme Length |
912 |
| Uniprot Accession Number |
Q9V3R1 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm. {ECO:0000269|PubMed:12939382, ECO:0000269|PubMed:9474779}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (2); Natural variant (26); Region (5); Signal peptide (1) |
| Keywords |
Behavior;Reference proteome;Secreted;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Proteolytically cleaved by the seminal metalloprotease Semp1 (PubMed:24514904). Cleavage appears to take place in the mated female (PubMed:24514904). {ECO:0000269|PubMed:24514904}. |
| Signal Peptide |
SIGNAL 1..23; /evidence=ECO:0000305 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10511562;
10531020;
10612039;
10790392;
10885514;
11095759;
11267893;
11291102;
11404480;
11412033;
11752406;
11782446;
11869341;
11932766;
12000098;
12351791;
12417656;
12679097;
12913117;
14602676;
14605208;
14668383;
15056610;
15215320;
15466425;
15601888;
15851659;
15944345;
15979005;
16670001;
17116868;
17276455;
17762866;
18067683;
18085830;
18245332;
18562649;
18666829;
18757944;
18836312;
19234471;
19343724;
19411605;
19576632;
19631203;
19805225;
20220848;
20833280;
21074052;
21269436;
21672851;
21940639;
22253601;
22384353;
23071443;
23087839;
23171073;
23555301;
23944235;
25294943;
25355478;
25425680;
25503806;
25742606;
26041806;
26058847;
26551273;
27794539;
28676322;
29055154;
29983616;
30293038;
31267577;
31740617;
32730707;
7479736;
7705622;
8290588;
8698082;
9014340;
9090115;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
101,921 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|