| IED ID | IndEnz0002014496 |
| Enzyme Type ID | protease014496 |
| Protein Name |
Beta-secretase EC 3.4.23.- |
| Gene Name | BACE |
| Organism | Strongylocentrotus purpuratus (Purple sea urchin) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Echinodermata Eleutherozoa Echinozoa Echinoidea (sea urchins) Euechinoidea Echinacea Camarodonta Echinidea Strongylocentrotidae Strongylocentrotus Strongylocentrotus purpuratus (Purple sea urchin) |
| Enzyme Sequence | MHFSLPTSRIVVVVPAAAICIVCVLIETCTAARSHVYTIPLRKGKETSFAETVGEPVRTNQVNVSVEEQKNNIRGRPGLGYYIEVDIGTPPQKLNVLIDTGSSNFAVAASSHNAISTYYRRNESSTYEDQGTYVKVPYTQGEWSGDLGQDLVQIASLGNQSFQANIAAITESKMFFLNDSRWQGILGLGYAEIARPDSSVEPFFDSLTSQTSIQDIFALQMCGALASTNDTNLGSSADGPVEEVIGSMNIGGLDASLYHGTMQYAPLRDEWFYEVIMTDIRVGNDSLGLDCKEYNFDKTIVDSGTTNLRLPVRVFEAITNAIKAHTTKHMPDVPSEFWTGMNLMCPTDSTSPYEPYHWFPTLTLDLQSTNQGQAFSLVVSPQQYLRRDYDHEDKKNCFKFAIAPSTNHAGAVIGAVIMEGFYVVFDRENKRVGFARSTCPGACEKTGTCVGNSPLITEAFNIDFDASDCGYDRSTSYDPALTITAYVLAAICLVCLIPVIVFALTHQINKRCKGRRGRGVVNHHRLDQEGLAENEPNSDP |
| Enzyme Length | 540 |
| Uniprot Accession Number | W8W138 |
| Absorption | |
| Active Site | ACT_SITE 99; /evidence=ECO:0000255|PROSITE-ProRule:PRU10094; ACT_SITE 302; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (3); Domain (1); Propeptide (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Aspartyl protease;Disulfide bond;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..31; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 59,336 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |