| IED ID | IndEnz0002014509 |
| Enzyme Type ID | protease014509 |
| Protein Name |
Beta-casein Cleaved into: Casoparan; Antioxidant peptide; Casohypotensin |
| Gene Name | CSN2 |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MKVLILACLVALALARELEELNVPGEIVESLSSSEESITRINKKIEKFQSEEQQQTEDELQDKIHPFAQTQSLVYPFPGPIPNSLPQNIPPLTQTPVVVPPFLQPEVMGVSKVKEAMAPKHKEMPFPKYPVEPFTESQSLTLTDVENLHLPLPLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSKVLPVPQKAVPYPQRDMPIQAFLLYQEPVLGPVRGPFPIIV |
| Enzyme Length | 224 |
| Uniprot Accession Number | P02666 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Important role in determination of the surface properties of the casein micelles.; FUNCTION: Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.; FUNCTION: Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.; FUNCTION: Antioxidant peptide has antioxidant activity. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous initiation (2); Frameshift (1); Modified residue (5); Natural variant (14); Peptide (3); Sequence conflict (8); Signal peptide (1) |
| Keywords | Antioxidant;Direct protein sequencing;Hypotensive agent;Metalloenzyme inhibitor;Metalloprotease inhibitor;Milk protein;Phosphoprotein;Protease inhibitor;Reference proteome;Secreted;Signal |
| Interact With | P0C0V0; Q8IXL6; O43464; O43464; P83110; P83105; P36776 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | MOD_RES 30; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:17510049, ECO:0000269|PubMed:4557764"; MOD_RES 32; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:17510049, ECO:0000269|PubMed:4557764"; MOD_RES 33; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:17510049, ECO:0000269|PubMed:4557764"; MOD_RES 34; /note="Phosphoserine"; /evidence="ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:17510049, ECO:0000269|PubMed:4557764"; MOD_RES 50; /note="Phosphoserine; in variant A1, variant A2, variant A3, variant B, variant E, variant F, variant G and variant H"; /evidence="ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:17510049" |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..15; /evidence="ECO:0000269|PubMed:10690361, ECO:0000269|PubMed:3278933, ECO:0000269|PubMed:4557764" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10971580; 17266347; 19563620; 24399684; 24520911; 24698088; |
| Motif | |
| Gene Encoded By | |
| Mass | 25,107 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |