| IED ID | IndEnz0002014531 |
| Enzyme Type ID | protease014531 |
| Protein Name |
Cathepsin L-like EC 3.4.22.15 |
| Gene Name | |
| Organism | Brugia pahangi (Filarial nematode worm) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Spirurina Spiruromorpha Filarioidea Onchocercidae Brugia Brugia pahangi (Filarial nematode worm) |
| Enzyme Sequence | MWTIAQLAVFAILALADFAVAGEIEQLKEVLGKFNKDYKQGNMTRLASDFRSALKEYGDGQQGESTVVQEFLKKTEDNGEQRAMEKLETEWKDYVTALGKHYDQKENNFRMAIFESNELMTERINKKYEQGLVSYTTALNDLADLTDEEFMVRNGLRLPNQTDLRGKRQTSEFYRYDKSERLPDQVDWRTKGAVTPVRNQGECGSCYAFATAAALEAYHKQMTGRLLDLSPQNIVDCTRNLGNNGCSGGYMPTAFQYASRYGIAMESRYPYVGTEQRCRWQQSIAVVTDNGFNEIQPGDELALKHAVAKRGPVVVGISGSKRSFRFYKDGVYSEGNCGRPDHAVLAVGYGTHPSYGDYWIVKNSWGTDWGKDGYVYMARNRGNMCHIASAASFPI |
| Enzyme Length | 395 |
| Uniprot Accession Number | O17473 |
| Absorption | |
| Active Site | ACT_SITE 206; /evidence=ECO:0000250; ACT_SITE 342; /evidence=ECO:0000250; ACT_SITE 363; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.; EC=3.4.22.15; |
| DNA Binding | |
| EC Number | 3.4.22.15 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Propeptide (1); Signal peptide (1) |
| Keywords | Disulfide bond;Hydrolase;Protease;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 44,549 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |