| IED ID | IndEnz0002014563 |
| Enzyme Type ID | protease014563 |
| Protein Name |
Cytochrome P450 71D179 Gamma-terpinene hydroxylase Thymol synthase EC 1.14.14.- |
| Gene Name | CYP71D179 |
| Organism | Origanum vulgare (Wild marjoram) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae asterids lamiids Lamiales Lamiaceae Nepetoideae Mentheae Origanum (marjorams) Origanum vulgare (Wild marjoram) |
| Enzyme Sequence | MDISISWVVIIVSVLSYLILMDKWRAAKLPKNIPPGPPKLPSIGHLHLLRGGLPQHLLRGITQQYGPVAHVQLGELFSVVLSSTEAARQAMKVLDPNFADRFVDIGSRIMWYDSEDIIFSRYNDHWRQIRKICVSELLSPKNVRSLGYIRQDEMASLIRLFESSEGKPVNVSEEISKTVCTIVSRVAFGSAVKDQSLLLNLVKESLRMASGFELADLFPSSWLLNLLCFNKYRLWRMRARLDNFLDGFLEEHRVKKSGEFGGEDIIDVLYRMQKDSQMKVPITNNGIKGFIYDVFSAGTDTSAATILWALSELTRYPEKMAKAPAEVRESLKGKTSVDLTEVHELKYLRSVVKEALRLHPPFPMTPRLCVQESEVTGYTIPANTRILINVWSIGRDPLYWEDPDTFNPDRYDEVPRDIIGNDFELIPFGSGRRICPGLHFGLANIEVPLAQLLYHFDWKLPPGMTAADIDMTEKTGLSGPRKNPLILVPIIHNPTS |
| Enzyme Length | 496 |
| Uniprot Accession Number | P0DO37 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 1.14.14.- |
| Enzyme Function | FUNCTION: Involved in the biosynthesis of phenolic monoterpenes natural products thymol and carvacrol which have a broad range of biological activities acting as antimicrobial compounds, insecticides, antioxidants and pharmaceutical agents (Ref.1, PubMed:26156773). Catalyzes probably the C3-hydroxylation of gamma-terpinene to produce thymol (Ref.1). {ECO:0000269|PubMed:26156773, ECO:0000303|Ref.1}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis. {ECO:0000303|Ref.1}. |
| nucleotide Binding | |
| Features | Chain (1); Metal binding (1); Transmembrane (1) |
| Keywords | Heme;Iron;Membrane;Metal-binding;Monooxygenase;Oxidoreductase;Signal-anchor;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | INDUCTION: Accumulates upon root colonization by Myrmica ants (Myrmica sabuleti and Myrmica scabrinodis) concomitantly with jasmonates induction; this leads to the production of carvacrol, an attractant for the phytophagous-predaceous butterfly Maculinea arion, whose larvae initially feed on Origanum vulgare flowerheads before switching to parasitize Myrmica ant colonies for their main period of growth (PubMed:26156773). Slightly repressed by Spodoptera littoralis, an herbivory insect (PubMed:30231481). {ECO:0000269|PubMed:26156773, ECO:0000269|PubMed:30231481}. |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 56,145 |
| Kinetics | |
| Metal Binding | METAL 435; /note=Iron (heme axial ligand); /evidence=ECO:0000250|UniProtKB:Q96242 |
| Rhea ID | |
| Cross Reference Brenda |