| IED ID | IndEnz0002014613 |
| Enzyme Type ID | protease014613 |
| Protein Name |
Probable dipeptidyl-aminopeptidase B DPAP B EC 3.4.14.5 |
| Gene Name | DAPB HCDG_08512 |
| Organism | Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Ajellomycetaceae Histoplasma Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) Ajellomyces capsulatus (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) |
| Enzyme Sequence | MATEKGHGRDDEERVPLTRGSTEFRNSIDSFDYSSSTASLSLAVIDRINNSTQDAALGEKGPRDDDDDRYWDDDVEYDVEDADYIPSGGKPMHKSVKIALWTLLFLSLGGWSLAFVLFIFRSHDTYETPISSEDNISSGGLRGDRITLDDVLGEEWMPRHHFISWFPGPNGEDGLLLEKDGLGSTGYLRVEDIVSRKDTKSSKGSIVLMQKNTFTVGGETVICSQVWPSPDLKTVLVLSEKKQNWRHSFTGKYWLFDVDTQTGQPLDPAAQDQRIQLASWSPQSDAVVFTRDNNMFLRKLSSKEVTTITSDGGVDLFYGVPDWVYEEEVFSGNSATWWAHDGNYIAFLRTNESAVPEYPVQYFVSRPSGEDPNLGEENYPEVREIKYPKAGAPNPIVDLQFYDVRKGEIFSVDVADRFPDDYRLIIEVLWASNGKILVRETNRESDILIIAAIDVLSRTGKIVRKEDINALDGGWVEPTQSTRFIPADPSNGRPEDGYIDTVIHEGRDQLAYFTPLDNPKPLILTKGPSEIVNSPSGVDLKRGLVYFVVAGNEPWERHVYSVKFDGTALQPVTNVSESSYYDVSFSDGAGYALLNFQGPKVPWQKVISTPANENPFEEIIEQNNHLSRKLRLFSLESKVFQYINIDGFSLPVLERRPPNFDPTKKYPVLFYLYGGPGSQTVDKKFRVDFQSYVASTLGYIVVTVDGRGTGYIGRKSRSIVRGKLGHYEARDQIEVAKKWAAKPYVDESRMAIWGWSYGGFMTLKTIEEDGGRTFQYGMAVAPVTDWRYYDSIYAERYMHTPQHNPQGYDSSAISNTTALANNVRFLVMHGTADDNVHIQNTLTLLDKLDLANVDNYDVHVFPDSNHNINFHNAHKIVYTRLADWLVNAFNGQWLKTNNPTPNDSLFRRAATWAGLSI |
| Enzyme Length | 917 |
| Uniprot Accession Number | C6HRC7 |
| Absorption | |
| Active Site | ACT_SITE 756; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 833; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 866; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; |
| DNA Binding | |
| EC Number | 3.4.14.5 |
| Enzyme Function | FUNCTION: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (1); Glycosylation (5); Region (1); Topological domain (2); Transmembrane (1) |
| Keywords | Aminopeptidase;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Signal-anchor;Transmembrane;Transmembrane helix;Vacuole |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Lysosome-like vacuoles. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 103,412 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |