Detail Information for IndEnz0002014943
IED ID IndEnz0002014943
Enzyme Type ID protease014943
Protein Name ATP-dependent protease subunit HslV
EC 3.4.25.2
Gene Name hslV A1G_02455
Organism Rickettsia rickettsii (strain Sheila Smith)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Alphaproteobacteria Rickettsiales Rickettsiaceae Rickettsieae Rickettsia spotted fever group Rickettsia rickettsii Rickettsia rickettsii (strain Sheila Smith)
Enzyme Sequence MSDNLSLHGTTILCLKKNEEIIIAADGQVSHGNTVLKSTARKLRTIANNKIIAGFAGSTADGLALFEKLAVKIEQHKHNLLRSAVELAKDWRSDKYLRRLEAMMIVADRSHILILTGNGDVVEPENNVAAIGSGGLFALSAARALMSYENNLTAEEIALKSMNIAADLCVFSNHNIIMEKVV
Enzyme Length 182
Uniprot Accession Number A8GRL7
Absorption
Active Site ACT_SITE 10; /evidence=ECO:0000255|HAMAP-Rule:MF_00248
Activity Regulation ACTIVITY REGULATION: Allosterically activated by HslU binding. {ECO:0000255|HAMAP-Rule:MF_00248}.
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=ATP-dependent cleavage of peptide bonds with broad specificity.; EC=3.4.25.2; Evidence={ECO:0000255|HAMAP-Rule:MF_00248};
DNA Binding
EC Number 3.4.25.2
Enzyme Function FUNCTION: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. {ECO:0000255|HAMAP-Rule:MF_00248}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Metal binding (3)
Keywords Allosteric enzyme;Cytoplasm;Hydrolase;Metal-binding;Protease;Sodium;Threonine protease
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00248}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 19,738
Kinetics
Metal Binding METAL 166; /note=Sodium; via carbonyl oxygen; /evidence=ECO:0000255|HAMAP-Rule:MF_00248; METAL 169; /note=Sodium; via carbonyl oxygen; /evidence=ECO:0000255|HAMAP-Rule:MF_00248; METAL 172; /note=Sodium; via carbonyl oxygen; /evidence=ECO:0000255|HAMAP-Rule:MF_00248
Rhea ID
Cross Reference Brenda