| IED ID | IndEnz0002015175 |
| Enzyme Type ID | protease015175 |
| Protein Name |
ATP-dependent protease subunit HslV EC 3.4.25.2 |
| Gene Name | hslV TM_0521 |
| Organism | Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) |
| Taxonomic Lineage | cellular organisms Bacteria Thermotogae Thermotogae Thermotogales Thermotogaceae Thermotoga Thermotoga maritima Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) |
| Enzyme Sequence | MKFHGTTILVVRRNGQTVMGGDGQVTFGSTVLKGNARKVRKLGEGKVLAGFAGSVADAMTLFDRFEAKLREWGGNLTKAAVELAKDWRTDRVLRRLEALLLVADKENIFIISGNGEVIQPDDDAAAIGSGGPYALAAAKALLRNTDLSAREIVEKAMTIAGEICIYTNQNIVIEEV |
| Enzyme Length | 176 |
| Uniprot Accession Number | Q9WYZ1 |
| Absorption | |
| Active Site | ACT_SITE 6; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Allosterically activated by HslU binding. {ECO:0000250}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=ATP-dependent cleavage of peptide bonds with broad specificity.; EC=3.4.25.2; Evidence={ECO:0000269|PubMed:12646382}; |
| DNA Binding | |
| EC Number | 3.4.25.2 |
| Enzyme Function | FUNCTION: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. {ECO:0000269|PubMed:12646382}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Beta strand (10); Chain (1); Helix (5); Metal binding (3); Propeptide (1); Turn (2) |
| Keywords | 3D-structure;Allosteric enzyme;Cytoplasm;Hydrolase;Metal-binding;Protease;Reference proteome;Sodium;Threonine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1M4Y; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 18,933 |
| Kinetics | |
| Metal Binding | METAL 161; /note=Sodium; via carbonyl oxygen; /evidence=ECO:0000269|PubMed:12646382; METAL 164; /note=Sodium; via carbonyl oxygen; /evidence=ECO:0000269|PubMed:12646382; METAL 167; /note=Sodium; via carbonyl oxygen; /evidence=ECO:0000269|PubMed:12646382 |
| Rhea ID | |
| Cross Reference Brenda |