| IED ID | IndEnz0002015290 |
| Enzyme Type ID | protease015290 |
| Protein Name |
Calpastatin Calpain inhibitor |
| Gene Name | CAST |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MNPTEAKAVKTEPEKKPQSSKPSVVHEKKTQEVKPKEHTEPKSLPKHSSDTGVKHAPKEKAVSKSSEQPPSEKSTKPKTKSQDKISGGGKSTVPAAAAAASAEPADKNKENKLLTSAVPAESKPSKPSGKSDMDTALDDLIDTLGEPEEMKEDNTTYTGPEVSDPMSSTYIEELGKRESTPPPKYKELLNKEEGIAGPPPDSLKPLGPNDAIDALSSDFTCSSLQLTTCSPTADGKETEKEKSTEEALKAQSAGVIRSAAPPKEKRRKVEEDTMTEQALQALSASLGTRKPEPELDPSSIREVDEAKAKEEKVKKCGEDEETVPSEYRLKPATDKDGKPLLPEAEEKPKPLSESELIDELSEDFDQSKPTEKQSKPTEKTEASPAAAPYPVAEDVPRTSMCSLQSAPPTAAPAKGMVPDDAVEALAGSLPKKEADPEDGKPVEDKVKEKAKEEDRENFGEKEETIPPDYRLEEAKDKDGKPLLPKEVKEPLPPLSEDVLLDALSKDFTVPSDTSSPQFEDAKLSAVVSEVVSQTPAPTTQAAGPPPDCARDNKELDDALDQLSDTLGQRQPDPDENKPVEDKVKEKAKAEHRDKLGERDDTIPPKYQHLLDDNKEGTPGKPKDQRAQGIRNCGEKPAGAQDPIDALSGDFDSCPSTTETSTDTPKDKDKKPASVPKHLGNGGKAKDSTKAKEETSKPKADGKSTS |
| Enzyme Length | 705 |
| Uniprot Accession Number | P20811 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (7); Cross-link (1); Modified residue (12); Region (3); Repeat (4); Sequence conflict (3) |
| Keywords | Acetylation;Direct protein sequencing;Isopeptide bond;Phosphoprotein;Protease inhibitor;Reference proteome;Repeat;Thiol protease inhibitor;Ubl conjugation |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 28; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:P51125; MOD_RES 65; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P51125; MOD_RES 115; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:P27321; MOD_RES 202; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P51125; MOD_RES 230; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810; MOD_RES 352; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810; MOD_RES 354; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810; MOD_RES 361; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810; MOD_RES 428; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810; MOD_RES 504; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810; MOD_RES 515; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810; MOD_RES 563; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P20810 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 75,843 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |